ENDEMIC GOITER IN MOROCCO - (SKOURA-TOUNDOUTE AREAS IN THE HIGH ATLAS)
ENDEMIC GOITER IN MOROCCO - (SKOURA-TOUNDOUTE AREAS IN THE HIGH ATLAS)
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DOI：
10.1007/bf03345821
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发表时间：
1993-01-01
影响因子：
5.4
通讯作者：
ARDISSONE, JP
中科院分区：
文献类型：
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作者：
AQUARON, R;ZARROUCK, K;ARDISSONE, JP
摩洛哥的地方性甲状腺肿集中在里夫山脉和阿特拉斯山脉。在这项在斯库拉-图杜特地区（高阿特拉斯）进行的研究中，我们证明缺碘是地方性甲状腺肿发生的主要因素。然而，它可能不是唯一的病因。在不定时样本中测量的尿碘排泄中位数在甲状腺肿患者中均较低，m = 18 微克/升 (n = 109)，在非甲状腺肿受试者中，m = 24 微克/升 (n = 47)。在非流行地区（卡萨布兰卡）发现的值要高得多 m=117 微克/升 (n=67)。评估每日碘摄入量的另一种方法是分析一些谷物（大麦、小麦和玉米）、饮用水、海盐和岩盐、牛奶和母乳样品的碘含量。碘含量低，特别是在流行地区：大麦=90μg/kg（n=1）；小麦=227 杯/公斤（n=1）；玉米=91 杯/公斤（n=1）；水=0.92至1.30杯/升(n=3)；牛奶=6至33杯/升（n=10） 母乳=10至55杯/升（n=14）；岩盐=420至660杯/千克（n=8）；海盐=90至160杯/千克（n=4）。通过测量钠和氯尿排泄量估算出的每日氯化钠摄入量在斯库拉-图杜特地区（甲状腺肿大和非甲状腺肿受试者分别为 10.7 克和 9.8 克）和卡萨布兰卡（对照者为 10.9 克）均正常。总而言之，结果证明了在该地区引入碘盐预防地方性甲状腺肿的重要性。
Endemic goiter in Morocco is localized in the Rif and Atlas mountains. In this study, performed in the Skoura-Toundoute areas (high Atlas), we demonstrate that iodine deficiency is the main factor involved in the development of endemic goiter. However it may not constitute the only etiological factor. The median urinary iodine excretion, measured on untimed samples, was low both in goitrous patients, m=18 mug/l (n=109) and in non goitrous subjects, m=24 mug/l (n=47). The value found in a nonendemic region (Casablanca) was much higher m=117 mug/l (n=67). Another approach to evaluate iodine intake per day was the analysis of iodine content of some samples of cereals (barley, wheat and corn), drinking water, sea and rock salt, cow and breast milk. Iodine content is low, specially in the endemic area: barley=90 mug/kg (n=1); wheat=227 mug/kg (n=1); corn=91 mug/kg (n=1); water=0.92 to 1.30 mug/l (n=3); cow milk=6 to 33 mug/l (n=10) breast milk=10 to 55 mug/l (n=14); rock salt=420 to 660 mug/kg (n=8); sea salt=90 to 160 mug/kg (n=4). Sodium chloride intake per day, estimated by the measurement of sodium and chloride urinary excretion, is normal both in the Skoura-Toundoute areas (10.7 g and 9.8 g for goitrous and nongoitrous subjects, respectively) and in Casablanca (10.9 g for control persons). Altogether the results demonstrate the importance of introducing the practice of iodinated salt in the prophylaxis of endemic goiter in this area.