Behavior-dependent short-term assembly dynamics in the medial prefrontal cortex
Behavior-dependent short-term assembly dynamics in the medial prefrontal cortex
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DOI：
10.1038/nn.2134
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发表时间：
2008-07-01
影响因子：
25
通讯作者：
Buzsaki, Gyoergy
中科院分区：
文献类型：
--
作者：
Fujisawa, Shigeyoshi;Amarasingham, Asohan;Buzsaki, Gyoergy
尽管据信短期可塑性在皮质计算中起着基本作用，但对其在行为中作用的经验证据很少。在这里，我们在工作记忆任务中，在大鼠内侧前额叶皮层中，在同时记录的生理上鉴定出的金字塔细胞和中间神经元的群体中，寻找了短期可塑性的签名。在更广泛的时间尺度上，依次组织和瞬时活跃的神经元可靠地分化了迷宫中大鼠的不同轨迹。在较小的时间尺度上，推定的单突触相互作用反映了在任务的各个方面的动态和可预测的调制中的短期可塑性，而不仅仅是统计学核算神经元共同触发率的影响。寻求潜在的机制来实现这种影响，我们发现了依赖模式的促进和抑郁症的证据，以及突触前重合对突触后靶标发射的上线作用。
Although short-term plasticity is believed to play a fundamental role in cortical computation, empirical evidence bearing on its role during behavior is scarce. Here we looked for the signature of short-term plasticity in the fine-timescale spiking relationships of a simultaneously recorded population of physiologically identified pyramidal cells and interneurons, in the medial prefrontal cortex of the rat, in a working memory task. On broader timescales, sequentially organized and transiently active neurons reliably differentiated between different trajectories of the rat in the maze. On finer timescales, putative monosynaptic interactions reflected short-term plasticity in their dynamic and predictable modulation across various aspects of the task, beyond a statistical accounting for the effect of the neurons' co-varying firing rates. Seeking potential mechanisms for such effects, we found evidence for both firing pattern-dependent facilitation and depression, as well as for a supralinear effect of presynaptic coincidence on the firing of postsynaptic targets.