Regulation of lymphocyte trafficking in central nervous system autoimmunity.
Regulation of lymphocyte trafficking in central nervous system autoimmunity.
复制标题
中枢神经系统自身免疫中淋巴细胞运输的调节。
DOI：
10.1016/j.coi.2018.09.008
复制
发表时间：
2018
影响因子：
7
通讯作者：
Bettelli,Estelle
中科院分区：
文献类型：
--
作者：
Oukka,Mohamed;Bettelli,Estelle
1-磷酸鞘氨醇（S1 P）阻断了幼稚T细胞、Th 17和TCM细胞从淋巴结中的流出。抑制S1 P/S1 P1信号通路改变了Treg的表型和功能。Treg可以独立于VLA 4进入中枢神经系统。在缺乏VLA 4/VCAM-1相互作用的情况下，其它粘附分子促进Treg和Th 17细胞进入CNS中。CD 4 + T辅助（Th）细胞在协调保护性免疫中以及在自身免疫中起中心作用。多发性硬化症（MS）是中枢神经系统（CNS）的人类自身免疫性疾病，其特征在于炎性淋巴细胞和骨髓细胞浸润到脑和脊髓中，导致脱髓鞘、轴突损伤和运动功能的进行性丧失。T细胞在循环中的释放及其在中枢神经系统中的迁移是关键和严格调节的过程，其目标是减少CNS中的CD 4 + T细胞存在并限制疾病进展。在这里，我们回顾这些途径中的两个，并讨论它们的封锁如何调节不同的CD 4 + T细胞亚群。
HighlightsSphingosine-1-phosphate (S1P) blocks the egress of naïve T cells, Th17, and TCM cells from the lymph nodes.Inhibition of the S1P/S1P1 signaling alters the phenotype and function of Treg.Treg can enter the CNS independently of VLA4.In the absence of VLA4/VCAM-1 interaction, other adhesion molecules promote the entry of Treg and Th17 cells in the CNS.CD4+ T helper (Th) cells play a central role in orchestrating protective immunity but also in autoimmunity. Multiple Sclerosis (MS) is a human autoimmune disease of the central nervous system (CNS) characterized by the infiltration of inflammatory lymphocytes and myeloid cells into the brain and spinal cord, leading to demyelination, axonal damage, and progressive loss of motor functions. The release of T cells in the circulation and their migration in the central nervous system are key and tightly regulated processes which have been targeted to decrease CD4+ T cell presence in the CNS and limit disease progression. Here, we review two of these pathways and discuss how their blockade modulate different subsets of CD4+ T cells.