Lyt-23+ cyclophosphamide-sensitive T cells regulate the activity of an interleukin 2 inhibitor in vivo
Lyt-23+ cyclophosphamide-sensitive T cells regulate the activity of an interleukin 2 inhibitor in vivo
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Lyt-23 环磷酰胺敏感 T 细胞调节体内白细胞介素 2 抑制剂的活性
DOI：
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发表时间：
1981
影响因子：
15.3
通讯作者：
H. Wagner
中科院分区：
文献类型：
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作者：
C. Hardt;M. Rollinghoff;K. Pfizenmaier;H. Mosmann;H. Wagner
携带胸腺的正常小鼠的血清含有高水平的白细胞介素2（II-2）抑制剂，而无胸腺nu/nu小鼠的血清不含。有证据表明，环磷酰胺敏感的Lyt-23+ T细胞诱导高II-2抑制剂活性的受体nu/nu小鼠的过程中，移植物对。宿主反应II-2抑制剂具有约50，000 mol wt.其功能既不是抗原特异性的，也不是H-2限制性的。在个体发育期间，其活性与T细胞反应性的发展平行，即，在未出生小鼠的羊水和血清中均不存在，但在出生后早期阶段增加到高水平。所述II-2抑制剂被视为T细胞依赖性体内调节机制的一个实例，其能够有效地抵消Lyt-1+辅助T细胞衍生的II-2的非特异性活性。由于II-2抑制剂在体内的活性相当高，因此II-2活性仅存在于其生产细胞附近，从而在细胞毒性T淋巴细胞的体内诱导期间保持特异性
Sera of thymus-bearing normal mice contain high levels of Interleukin 2 (II-2) inhibitor, whereas sera of athymic nu/nu mice do not. Evidence is presented that cyclophosphamide-sensitive Lyt-23+ T cells induce high II-2 inhibitor activity in the recipient nu/nu mice in the course of a graft-vs.-host reaction. The II-2 inhibitor has an approximately 50,000 mol wt. Its function is neither antigen specific nor H-2 restricted. During ontogeny, its activity parallels the development of T cell reactivity, i.e., it is absent both in the amniotic fluid and in sera of unborn mice, but increases to high levels during the early postnatal phase. The II-2 inhibitor described is viewed as an example of a T cell-dependent, in vivo regulatory mechanism able to effectively counteract the nonspecific activity of the Lyt-1+ helper T cell-derived II-2. Because the II-2 inhibitor activity is rather high in vivo, II-2 activity will exist only in close proximity to its producer cell, thereby maintaining specificity during the in vivo induction of cytotoxic T lymphocytes