Neuroticism and white matter hyperintensities.
Neuroticism and white matter hyperintensities.
复制标题
神经质和白质高信号。
DOI：
10.1016/j.jpsychires.2023.07.026
复制
发表时间：
2023
影响因子：
4.8
通讯作者：
Sutin,AngelinaR
中科院分区：
文献类型：
--
作者：
Terracciano,Antonio;Cenatus,Bertin;Zhu,Xianghe;Karakose,Selin;Stephan,Yannick;Marcolini,Sofia;DeDeyn,PeterP;Luchetti,Martina;Sutin,AngelinaR
神经质是神经退行性疾病（例如阿尔茨海默病和相关痴呆症）的主要危险因素。这项研究调查了神经质是否与白质高信号相关，以及这种大脑完整性的测量是否是神经质和认知功能之间的中介因素。来自英国生物银行的中老年人（N = 40,602；年龄 45-82 岁，M = 63.97，SD = 7.66）提供了人口统计和健康协变量的信息，完成了神经质和认知的测量，并接受了磁共振成像，从中得出白质高信号的体积。以年龄和性别为协变量的回归分析发现，神经质得分较高的参与者白质高信号较多（β = 0.024，95% CI 0.015 至 0.032；p < .001），这种关联在脑室周围和大脑深部区域是一致的。当考虑到血管危险因素（吸烟、肥胖、糖尿病、高血压、心脏病、心绞痛和中风）时，这种关联性降低了约 40%。这种关联不受年龄、性别、大学教育、剥夺指数或 APOE e4 基因型的调节，并且在排除痴呆症患者或 65 岁以下个体的敏感性分析中保持不变。中介分析显示，白质高信号部分介导了神经质和认知功能之间的关联。这些发现将白质完整性确定为一种潜在的神经生物学途径，在神经质与认知健康之间的关联中占一小部分。
Neuroticism is a major risk factor for neurodegenerative disorders, such as Alzheimer's disease and related dementias. This study investigates whether neuroticism is associated with white matter hyperintensities and whether this measure of brain integrity is a mediator between neuroticism and cognitive function. Middle-aged and older adults from the UK Biobank (N = 40,602; aged 45–82 years, M = 63.97, SD = 7.66) provided information on demographic and health covariates, completed measures of neuroticism and cognition, and underwent magnetic resonance imaging from which the volume of white matter hyperintensities was derived. Regression analyses that included age and sex as covariates found that participants who scored higher on neuroticism had more white matter hyperintensities (β = 0.024, 95% CI 0.015 to 0.032; p < .001), an association that was consistent across peri-ventricular and deep brain regions. The association was reduced by about 40% when accounting for vascular risk factors (smoking, obesity, diabetes, high blood pressure, heart attack, angina, and stroke). The association was not moderated by age, sex, college education, deprivation index, or APOE e4 genotype, and remained unchanged in sensitivity analyses that excluded individuals with dementia or those younger than 65. The mediation analysis revealed that white matter hyperintensities partly mediated the association between neuroticism and cognitive function. These findings identify white matter integrity as a potential neurobiological pathway that accounts for a small proportion of the association between neuroticism and cognitive health.