Nodular ground-glass opacities on thin-section CT: size change during follow-up and pathological results.
Nodular ground-glass opacities on thin-section CT: size change during follow-up and pathological results.
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DOI：
10.3348/kjr.2007.8.1.22
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发表时间：
2007-01
影响因子：
4.8
通讯作者：
Im JG
中科院分区：
文献类型：
--
作者：
Lee HJ;Goo JM;Lee CH;Yoo CG;Kim YT;Im JG
根据结节性毛玻璃混浊（GGO）的大小和局灶性实性部分评估其生长和病理结果的组间差异。其中包括 55 名个体的 96 个结节性 GGO，并在初次胸部 CT 后至少一个月进行 CT 检查。 30 例患者中 40 个结节性 GGO 经病理证实为：腺癌（n = 15）、细支气管肺泡癌（BAC）（n = 11）、非典型腺瘤性增生（AAH）（n = 8）、局灶性间质纤维化（n = 5）和曲霉菌病（n = 1）。根据高分辨率 CT 结果对病变进行分类：纯结节性 GGO (PNGGO) ≤ 10 mm、PNGGO > 10 mm、混合结节性 GGO (MNGGO) ≤ 10 mm 和 MNGGO > 10 mm。评价各组随访期间体积变化、病理结果及恶性率。在随访期间，三个 MNGGO 病变（但没有一个 PNGGO）生长。切除的 PNGGO ≤ 10 mm 为 AAH (n = 6)、BAC (n = 5) 和局灶性间质纤维化 (n = 1)。切除的 PNGGO > 10 mm 为局灶性间质纤维化 (n = 4)、AAH (n = 2)、BAC (n = 2) 和腺癌 (n = 2)。切除的 MNGGO ≤ 10 mm 为腺癌 (n = 2) 和 BAC (n = 1)。切除的 MNGGO > 10 mm 为腺癌 (n = 11)、BAC (n = 3) 和曲霉病 (n = 1)。混合结节状 GGO（MNGGO）具有生长潜力；大多数病理学上是腺癌或 BAC。相比之下，PNGGO 可以稳定数月至数年；大多数是 AAH、BAC 或局灶性间质纤维化。
To evaluate the inter-group differences in growth and the pathological results of nodular ground-glass opacities (GGOs) according to their size and focal solid portions. Ninety-six nodular GGOs in 55 individuals followed by CT for at least one month from an initial chest CT were included. Forty nodular GGOs in 30 individuals were pathologically confirmed to be: adenocarcinoma (n = 15), bronchioloalveolar carcinoma (BAC) (n = 11), atypical adenomatous hyperplasia (AAH) (n = 8), focal interstitial fibrosis (n = 5) and aspergillosis (n = 1). Lesions were categorized based on high-resolution CT findings: pure nodular GGO (PNGGO) ≤ 10 mm, PNGGO > 10 mm, mixed nodular GGO (MNGGO)≤ 10 mm, and MNGGO > 10 mm. In each group, the change in size during the follow-up period, the pathological results and the rate of malignancy were evaluated. Three MNGGO lesions, and none of the PNGGO, grew during the follow-up period. Resected PNGGOs ≤ 10 mm were AAH (n = 6), BAC (n = 5), and focal interstitial fibrosis (n = 1). Resected PNGGOs > 10 mm were focal interstitial fibrosis (n = 4), AAH (n = 2), BAC (n = 2), and adenocarcinoma (n = 2). Resected MNGGOs ≤ 10 mm were adenocarcinoma (n = 2), and BAC (n = 1). Resected MNGGOs > 10 mm were adenocarcinoma (n = 11), BAC (n = 3), and aspergillosis (n = 1). Mixed nodular GGOs (MNGGOs) had the potential for growth; most were pathologically adenocarcinoma or BAC. By contrast, PNGGOs were stable for several months to years; most were AAH, BAC, or focal interstitial fibrosis.