Measurement of Thoracic Bone Mineral Density with Quantitative CT
Measurement of Thoracic Bone Mineral Density with Quantitative CT
复制标题
DOI：
10.1148/radiol.10100132
复制
发表时间：
2010-11-01
期刊：
影响因子：
19.7
通讯作者：
Mao, Songshou
中科院分区：
文献类型：
--
作者：
Budoff, Matthew J.;Hamirani, Yasmin S.;Mao, Songshou
目的：建立标准的胸部骨密度（BMD）值进行心脏计算机断层扫描（CT）的患者，通过使用胸部定量CT和比较这些BMD（在一个亚群）与腰椎定量CT.Materials和方法获得的：机构审查委员会批准了这项符合健康保险责任法案的研究。共有9585名无症状受试者（平均年龄56岁，年龄范围30-90岁）接受冠状动脉钙扫描，其中包括4131名女性，进行了检查。排除了椎体畸形或骨折患者。644例受试者（其中322例为女性）还接受了腰椎定量CT。在年龄30岁的受试者亚组和29个基于年龄的亚组中分别报告了两种性别的平均胸椎BMD，时间间隔为2年，从30岁至90岁。根据胸部定量CT测量值计算女性T评分（T-f）和男性T评分（T-m）的公式如下：T-f =（BMDim 2 222）/36，T-m =（BMDim 2 215）/33，其中BMDim为个体平均BMD。比较胸部定量CT和腰部定量CT测量值，并分析观察者内、观察者间和扫描间变异性。结果：女性受试者的年轻亚组平均BMD为221.9 mg/mL +/- 36.2（标准差），男性受试者为215.2 mg/mL +/- 33.2。女性和男性受试者的平均胸部BMD分别比腰椎定量CT测量值高20.7%和17.0%（两种比较均P <0.001）。胸腰椎定量CT测量值之间存在显著正相关（r。> 0.85，P <0.001）。胸部定量CT测量的观察者内、观察者间和扫描间变异性分别为2.5%、2.6%和2.8%.Conclusion：胸腰椎平均BMD之间存在显著相关性。因此，基于这些数据的标准衍生测量值（亚组BMD 6标准差）可与胸部CT图像一起用于估计骨矿物质状态。(C)RSNA，2010年
Purpose: To create standard thoracic bone mineral density (BMD) values for patients undergoing cardiac computed tomography (CT) by using thoracic quantitative CT and to compare these BMDs (in a subpopulation) with those obtained by using lumbar spine quantitative CT.Materials and Methods: The institutional review board approved this HIPAA-compliant study. A total of 9585 asymptomatic subjects (mean age, 56 years; age range, 30-90 years) who underwent coronary artery calcium scanning, including 4131 women, were examined. Patients with vertebral deformities or fractures were excluded. Six hundred forty-four subjects (322 of whom were female) also underwent lumbar quantitative CT. The mean thoracic vertebral BMDs for both sexes were reported separately in a subgroup of subjects aged 30 years and in 29 age-based subgroups in 2-year intervals from ages 30 to 90 years. The formulas used to calculate the female T score (T-f) and the male T score (T-m) on the basis of thoracic quantitative CT measurements were as follows: T-f = (BMDim 2 222)/36, and T-m = (BMDim 2 215)/33, where BMDim is the individual mean BMD. Comparisons between thoracic quantitative CT and lumbar quantitative CT measurements, as well as analyses of intraobserver, interobserver, and interscan variability, were performed.Results: The young-subgroup mean BMD was 221.9 mg/mL +/- 36.2 (standard deviation) for the female subjects and 215.2 mg/mL +/- 33.2 for the male subjects. The mean thoracic BMDs for the female and male subjects were found to be 20.7% higher and 17.0% higher, respectively, than the values measured with lumbar quantitative CT (P < .001 for both comparisons). A significant positive association between the thoracic and lumbar quantitative CT measurements (r. > 0.85, P < .001) was found. Intraobserver, interobserver, and interscan variabilities in thoracic quantitative CT measurements were 2.5%, 2.6%, and 2.8%, respectively.Conclusion: There was a significant association between the mean thoracic and lumbar BMDs. Therefore, standard derived measurements (young-subgroup BMD 6 standard deviation) based on these data can be used with thoracic CT images to estimate the bone mineral status. (C) RSNA, 2010