Vitamin D Deficiency, Smoking, and Lung Function in the Normative Aging Study
Vitamin D Deficiency, Smoking, and Lung Function in the Normative Aging Study
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DOI：
10.1164/rccm.201110-1868oc
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发表时间：
2012-10-01
影响因子：
24.7
通讯作者：
Litonjua, Augusto A.
中科院分区：
文献类型：
--
作者：
Lange, Nancy E.;Sparrow, David;Litonjua, Augusto A.
理由：维生素D具有免疫调节和抗炎作用，可能被吸烟改变，并可能影响肺功能。目的：探讨维生素D缺乏和吸烟对肺功能及肺功能衰退的影响。方法：从1984年到2003年，共有626名男性在三个不同的时间用同步肺活量测定法测量了25-羟基维生素D水平。维生素D缺乏症被定义为血清水平
Rationale: Vitamin D has immunomodulatory and antiinflammatory effects that may be modified by cigarette smoke and may affect lung function.Objectives: To examine the effect of vitamin D deficiency and smoking on lung function and lung function decline.Methods: A total of 626 men from the Normative Aging Study had 25-hydroxyvitamin D levels measured at three different times between 1984 and 2003 with concurrent spirometry. Vitamin D deficiency was defined as serum level