Previous Infection Combined with Vaccination Produces Neutralizing Antibodies with Potency against SARS-CoV-2 Variants.
Previous Infection Combined with Vaccination Produces Neutralizing Antibodies with Potency against SARS-CoV-2 Variants.
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DOI：
10.1128/mbio.02656-21
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发表时间：
2021-12-21
期刊：
影响因子：
6.4
通讯作者：
Yang OO
中科院分区：
文献类型：
--
作者：
Ibarrondo FJ;Hofmann C;Ali A;Ayoub P;Kohn DB;Yang OO
严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 继续在人类中进化。刺突蛋白突变会增加传播并可能逃避针对当前疫苗中使用的原始序列产生的抗体。我们对 SARS-CoV-2 感染后不久（2020 年 4 月或更早）或在未感染前接种疫苗后不久对两人的血清中和活性进行的评估证实，常见的尖峰突变可以降低抗体的抗病毒活性。然而，当先前感染的人随后接种疫苗时，他们的抗体达到了针对所有测试变体的中和效力的明显生物学上限，相当于原始的刺突序列。这些发现表明额外的抗原暴露进一步提高了抗体针对变体的功效。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve in humans. Spike protein mutations increase transmission and potentially evade antibodies raised against the original sequence used in current vaccines. Our evaluation of serum neutralizing activity in both persons soon after SARS-CoV-2 infection (in April 2020 or earlier) or vaccination without prior infection confirmed that common spike mutations can reduce antibody antiviral activity. However, when the persons with prior infection were subsequently vaccinated, their antibodies attained an apparent biologic ceiling of neutralizing potency against all tested variants, equivalent to the original spike sequence. These findings indicate that additional antigenic exposure further improves antibody efficacy against variants.