Therapeutic applications of microbubbles
Therapeutic applications of microbubbles
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DOI：
10.1016/s0720-048x(01)00455-7
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发表时间：
2002-05-01
影响因子：
3.3
通讯作者：
Quigley, R
中科院分区：
文献类型：
--
作者：
Unger, EC;Matsunaga, TO;Quigley, R
目前用作造影剂的微泡具有潜在的治疗应用;微泡在足够强的超声作用下会空化。微泡的气穴作用可用于溶解血栓或输送药物。靶向配体和药物可以掺入微泡中，以制备高度特异性的诊断和治疗剂，用于超声激活。在本文中，我将回顾这些潜在的应用和实验结果，使用这样的代理溶栓，药物和基因传递。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Microbubbles, currently used as contrast agents have potential therapeutic application;. Microbubbles, upon insonation of sufficiently intense ultrasound will cavitate. Cavitation with microbubbles can be used to dissolve blood clots or deliver drugs. Targeting ligands and drugs can be incorporated into microbubbles to make highly specific diagnostic and therapeutic agents for activation with ultrasound. In this paper I will review some of these potential applications and experimental results using such agents for thrombolysis, drug and gene delivery. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.