Epidemiology of inflammation and prostate cancer.
Epidemiology of inflammation and prostate cancer.
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DOI：
10.1097/01.ju.0000108131.43160.77
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发表时间：
2004-02-01
影响因子：
6.6
通讯作者：
De Marzo, Angelo M.
中科院分区：
文献类型：
--
作者：
Platz, Elizabeth A.;De Marzo, Angelo M.
目的：我们提供了一些基础，临床和流行病学研究的概述，已进行调查慢性炎症在前列腺癌发生中的潜在作用，并为这一假设的未来研究提供方向。材料和方法：我们回顾了这方面的文献。结果如下：长期以来，慢性炎症一直与炎症性肠病患者中具有感染性病因的癌症有关，例如胃癌、肝癌和结肠癌。前列腺内炎症是否有助于前列腺癌的发生尚不清楚。炎症经常存在于前列腺活检、根治性前列腺切除术标本和为治疗良性前列腺增生而切除的组织中。此外，炎性浸润通常在以增殖指数增加为特征的萎缩灶内和周围发现。这些病灶称为增生性炎性萎缩，可能是早期前列腺癌的前兆，也可能表明前列腺内环境有利于癌症的发展。流行病学研究通过对促炎和抗炎因子的研究间接地检查了慢性炎症在前列腺癌发生中的作用。当综合考虑性传播感染、临床前列腺炎、炎症和对感染的反应的遗传和循环标志物的研究时，慢性前列腺内炎症和前列腺癌之间存在联系。结论：需要额外的精心设计的基础，临床和流行病学研究来解决慢性炎症在前列腺癌发生中的作用，并确定前列腺内炎症是否是化学预防的合理目标。
Purpose: We provide an overview of some of the basic, clinical and epidemiological research that has been conducted to investigate the potential role of chronic inflammation in prostate carcinogenesis and to provide direction for future research on this hypothesis. Materials and Methods: We reviewed the literature on this topic. Results: Chronic inflammation has long been linked to cancers with an infectious etiology, such as stomach, liver and colon cancer, in patients with inflammatory bowel disease. Whether intraprostatic inflammation contributes to prostate carcinogenesis is unknown. Inflammation is frequently present in prostate biopsies, radical prostatectomy specimens and tissue resected for treatment of benign prostatic hyperplasia. Also, inflammatory infiltrates are often found in and around foci of atrophy that are characterized by an increased proliferative index. These foci, called proliferative inflammatory atrophy, may be precursors of early prostate cancer or may indicate an intraprostatic environment favorable to cancer development. Epidemiological studies have indirectly examined the role of chronic inflammation in prostate carcinogenesis through studies of pro-inflammatory and anti-inflammatory factors. When taken together studies of sexually transmitted infections, clinical prostatitis, and genetic and circulating markers of inflammation and response to infection hint at a link between chronic intraprostatic inflammation and prostate cancer. Conclusions: Additional well-designed basic, clinical and epidemiological studies are needed to resolve questions about the role of chronic inflammation in prostate carcinogenesis and to determine if intraprostatic inflammation is a rational target for chemoprevention.