Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS
Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS
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DOI：
10.1182/blood-2005-03-1159
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发表时间：
2005-09-01
期刊：
影响因子：
20.3
通讯作者：
Swinkels, D
中科院分区：
文献类型：
--
作者：
Kemna, E;Pickkers, P;Swinkels, D
肝肽激素hepcidin是铁代谢的关键调节剂，也是炎症性贫血的介导剂。以往的研究表明，白细胞介素-6（IL-6）介导的铁调素增加，从而导致低铁血症在炎症。在这里，我们使用了体内人内毒素血症模型来分析脂多糖（LPS）作为更上游的炎症激活剂的作用。研究了10名健康人注射LPS后血浆细胞因子、铁调素水平和血清铁参数之间的时间相关性。IL-6在注射后3小时内显著诱导，尿铁调素在6小时内达到峰值，随后血清铁显著降低。血清铁调素原在22小时时间范围内未显示显著变化。这些人体体内结果证实了IL-6-铁调素轴在炎症中低铁血症发展中的重要性，并突出了该铁调节系统的快速反应性。
Hepatic peptide hormone hepcidin is the key regulator of iron metabolism and the mediator of anemia of inflammation. Previous studies indicated that interleukin-6 (IL-6) mediates hepcidin increase and consequent hypoferremia during inflammation. Here we used an in vivo human endotoxemia model to analyze the effects of lipopolysaccharide (LPS) as a more upstream inflammation activator. The temporal associations between plasma cytokines, hepcidin levels, and serum iron parameters were studied in 10 healthy individuals after LPS injection. IL-6 was dramatically induced within 3 hours after injection, and urinary hepcidin peaked within 6 hours, followed by a significant decrease in serum iron. Serum prohepcidin showed no significant change within a 22-hour time frame. These in vivo human results confirm the importance of the IL-6-hepcidin axis in the development of hypoferremia in inflammation and highlight the rapid responsiveness of this iron regulatory system.