Associations between Circle of Willis Morphology and White Matter Lesion Load in Subjects with Carotid Artery Stenosis
Associations between Circle of Willis Morphology and White Matter Lesion Load in Subjects with Carotid Artery Stenosis
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DOI：
10.1159/000329274
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发表时间：
2011-01-01
影响因子：
2.4
通讯作者：
Lee, Tsong-Hai
中科院分区：
文献类型：
--
作者：
Chuang, Yu-Ming;Huang, Kuo-Lun;Lee, Tsong-Hai
背景：脑白质疏松症（leukoaraiosis，LA）是由多种脑组织病理改变引起的.我们假设Willis环（CoW）异常可能通过受损的脑自动调节导致严重颈动脉狭窄患者的LA。我们对严重症状性颈动脉狭窄患者的脑磁共振（MR）模式进行了回顾性分析，并比较了有和没有完全CoW的受试者之间的白色病变（WML）负荷。研究方法：对106例单侧颈动脉狭窄患者（64例男性和42例女性;平均年龄68.7 ± 9.2岁，范围44-82岁）在半卵圆中心和两个大脑半球的前角水平的液体衰减反转恢复（FLAIR）MR图像上的LA进行评分。根据脑MR血管造影将受试者分为完全CoW组和不完全CoW组。进一步分析完全和不完全CoW组之间LA评分的差异。结果如下：与CoW构型不完整的受试者相比，CoW构型完整的受试者在半卵圆中心水平（2.78 +/- 1.17 vs. 5.62 +/- 2.12，p = 0.02）和前角水平（2.21 +/- 0.79 vs. 4.22 +/- 1.83，p = 0.01）的WML负荷降低。结论：我们的研究结果支持了完整CoW的重要性，因为它可以防止颈动脉狭窄时发生WML。版权所有（C）2011 S. Karger AG，巴塞尔
Background: Various cerebral pathological changes have been reported to cause leukoaraiosis (LA). We hypothesized that circle of Willis (CoW) anomalies may contribute to LA in severe carotid artery stenosis victims through impaired cerebral autoregulation. We conducted a retrospective review on cerebral magnetic resonance (MR) patterns in patients with severe symptomatic carotid artery stenosis and compared white matter lesion (WML) load between subjects with and without complete CoW. Methods: LA on fluid attenuation inversion recovery (FLAIR) MR images at the levels of the centrum semiovale and frontal horns in both cerebral hemispheres were scored in 106 patients with unilateral carotid artery stenosis (64 men and 42 women; mean age 68.7 +/- 9.2 years, range 44-82). Subjects were divided into groups of complete and incomplete CoW according to cerebral MR angiography. Differences in the LA scores between the groups of complete and incomplete CoW were further analyzed. Results: Compared with those with incomplete configuration of the CoW, subjects with a complete CoW demonstrated a decreased WML load at the level of the centrum semiovale (2.78 +/- 1.17 vs. 5.62 +/- 2.12, p = 0.02) and frontal horns (2.21 +/- 0.79 vs. 4.22 +/- 1.83, p = 0.01). Conclusion: Our results support the importance of a complete CoW since it may protect from WML in case of carotid stenosis. Copyright (C) 2011 S. Karger AG, Basel