POLYMERS FOR BIODEGRADABLE MEDICAL DEVICES .2. HYDROXYBUTYRATE-HYDROXYVALERATE COPOLYMERS - HYDROLYTIC DEGRADATION STUDIES
POLYMERS FOR BIODEGRADABLE MEDICAL DEVICES .2. HYDROXYBUTYRATE-HYDROXYVALERATE COPOLYMERS - HYDROLYTIC DEGRADATION STUDIES
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DOI：
10.1016/0142-9612(87)90117-7
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发表时间：
1987-07-01
期刊：
影响因子：
14
通讯作者：
TIGHE, BJ
中科院分区：
文献类型：
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作者：
HOLLAND, SJ;JOLLY, AM;TIGHE, BJ
研究了聚羟基丁酸酯和一系列羟基丁酸酯-羟基戊酸酯共聚物的水解降解。的共聚物组合物和分子量的影响，连同不同的pH值和温度的降解速率的结果。通过重量损失和吸水测量以及测角光度、表面能和扫描电子显微镜研究监测了降解情况。与更广泛使用的所谓的“生物可降解"聚合物，聚（乙醇酸），聚（二氧环己酮）和乙醇酸-乳酸（90：10）共聚物的一些比较，以及血浆对降解过程的影响。
The hydrolytic degradation of poly(hydroxybutyrate) together with a series of hydroxybutyrate-hydroxyvalerate copolymers has been studied. The effects of copolymer composition and molecular weight are presented together with the results of varying pH and temperature on the degradation rate. Degradation has been monitored by weight loss and water uptake measurements together with goniophotometric, surface energy and scanning electron microscopic studies. Some comparisons with the more widely used so-called ''biodegradable'' polymers, poly(glycolic acid), poly(dioxanone) and the glycolic-lactic acid (90:10) copolymers are presented together with the effect of blood plasma on the degradation process.