ANALYSIS OF IL-6 LEVELS IN HUMAN VITREOUS FLUID OBTAINED FROM UVEITIS PATIENTS, PATIENTS WITH PROLIFERATIVE INTRAOCULAR DISORDERS AND EYE BANK EYES
ANALYSIS OF IL-6 LEVELS IN HUMAN VITREOUS FLUID OBTAINED FROM UVEITIS PATIENTS, PATIENTS WITH PROLIFERATIVE INTRAOCULAR DISORDERS AND EYE BANK EYES
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DOI：
10.3109/02713689208999530
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发表时间：
1992-01-01
影响因子：
2
通讯作者：
KIJLSTRA, A
中科院分区：
文献类型：
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作者：
DEBOER, JH;VANHAREN, MAC;KIJLSTRA, A
一些研究表明IL-6在葡萄膜炎的发病机制中起作用。早些时候，我们已经表明从葡萄膜炎患者获得的房水含有升高的IL-6水平。在本文所述的研究中，我们调查了75例不同葡萄膜炎实体的葡萄膜炎患者的玻璃体液样本中的IL-6水平。以14例增殖性眼内病变（PID）患者和29例眼库眼的玻璃体标本作为对照。所有样本均进行IL-6 B9生物测定和IL-6敏感ELISA检测。在葡萄膜炎患者和PID患者的玻璃体液中检测到IL-6水平升高，提示IL-6是一种常见的炎症介质。急性视网膜坏死患者玻璃体液中IL-6的平均水平最高。ELISA测定的平均IL-6水平高于B9生物测定法测定的水平。这可能是由于这些患者玻璃体液中存在B9生物测定抑制因子所致。
Several studies suggest a role for IL-6 in the pathogenesis of uveitis. Earlier we have shown that aqueous humour obtained from patients with uveitis contained raised levels of IL-6. In the study described here we investigated the IL-6 levels in vitreous fluid samples obtained from 75 uveitis patients with different uveitis entities. Vitreous samples from 14 patients with proliferative intraocular disorders (PID) and 29 eye bank eyes were used as controls. All the samples were tested in the IL-6 B9 bioassay as well as in a sensitive ELISA for IL-6.Raised IL-6 levels were detected in the vitreous fluid of uveitis patients as well as patients with PID, implicating IL-6 as a common inflammatory mediator. The highest mean level of IL-6 was found in the vitreous fluid of patients with acute retinal necrosis. The mean IL-6 levels measured by the ELISA were higher compared to the levels measured by the B9 bioassay. This may be caused by the presence of B9 bioassay inhibitory factors in the vitreous fluid of these patients.