Telomere dysfunction: A potential cancer predisposition factor
Telomere dysfunction: A potential cancer predisposition factor
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DOI：
10.1093/jnci/djg011
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发表时间：
2003-08-20
期刊：
影响因子：
--
通讯作者：
Spitz, MR
中科院分区：
文献类型：
--
作者：
Wu, XF;Amos, CI;Spitz, MR
背景：与端粒功能障碍相关的遗传不稳定性（即，短端粒）是肿瘤发生的早期事件。我们在四项正在进行的病例对照研究中调查了端粒长度与癌症风险之间的关系。研究方法：所有研究的病例患者和对照受试者数量相同（头颈癌92例，膀胱癌135例，肺癌54例，肾细胞癌32例）。端粒长度测量研究参与者外周血淋巴细胞。用彗星试验评估遗传不稳定性。收集并分析患者和疾病特征与这些癌症风险的相关性。所有统计检验均为双侧检验。结果如下：头颈癌患者的端粒（6.5 kb）比对照组（7.4 kb）短，差异有统计学意义（差异= 0.9 kb，95%置信区间[CI] = 0.5 - 1.2 kb; P
Background: Genetic instability associated with telomere dysfunction (i.e., short telomeres) is an early event in tumorigenesis. We investigated the association between telomere length and cancer risk in four ongoing case-control studies. Methods: All studies had equal numbers of case patients and matched control subjects (92 for head and neck cancer, 135 for bladder cancer, 54 for lung cancer, and 32 for renal cell carcinoma). Telomere length was measured in peripheral blood lymphocytes from study participants. Genetic instability was assessed with the comet assay. Patient and disease characteristics were collected and analyzed for associations with risk for these cancers. All statistical tests were two-sided. Results: Telomeres were statistically significantly shorter in patients with head and neck cancer (6.5 kilobases [kb]) than in control subjects (7.4 kb) (difference = 0.9 kb, 95% confidence interval [CI] = 0.5 to 1.2 kb; P