Case-control study of risk of Parkinson's disease in relation to hypertension, hypercholesterolemia, and diabetes in Japan
Case-control study of risk of Parkinson's disease in relation to hypertension, hypercholesterolemia, and diabetes in Japan
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DOI：
10.1016/j.jns.2010.03.002
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发表时间：
2010-06-15
影响因子：
4.4
通讯作者：
Nagai, Masaki
中科院分区：
文献类型：
--
作者：
Miyake, Yoshihiro;Tanaka, Keiko;Nagai, Masaki
本病例对照研究调查了日本高血压、高胆固醇血症和糖尿病史与帕金森病（PD）风险的关系。纳入了PD发作6年内的249例病例。对照组为368例无神经退行性疾病的住院和门诊患者。血管危险因素和混杂因素的数据从自填问卷中获得。根据药物治疗定义血管危险因素。对性别、年龄、居住地区、吸烟年数、受教育年限、闲暇时间锻炼、体重指数、膳食能量摄入、胆固醇、维生素E进行了调整。酒精，咖啡和饮食血糖指数。在病例中，PD发作前高血压、高胆固醇血症和糖尿病的比例分别为23.7%、9.6%和4.0%。高血压、高胆固醇血症和糖尿病与PD风险降低显著相关：调整后的OR分别为0.43（95% CI：0.29-0.64）、0.58（95% CI：0.33-0.97）和0.38（95% CI：0.17-0.79）。在男性和女性之间，血管危险因素与PD风险的相关性无显著差异。在日本，我们发现高血压、高胆固醇血症和糖尿病与PD风险显著负相关的证据。需要进一步设计良好的研究血管危险因素与PD风险的相关性，特别是在亚洲的大规模前瞻性研究。(C)2010 Elsevier B. V.保留所有权利。
This case-control study investigated the associations of a history of hypertension, hypercholesterolemia, and diabetes mellitus with the risk of Parkinson's disease (PD) in Japan. Included were 249 cases within 6 years of onset of PD. Controls were 368 inpatients and outpatients without a neurodegenerative disease. Data on the vascular risk factors and confounders were obtained from a self-administered questionnaire. The vascular risk factors were defined based on drug treatment. Adjustment was made for sex, age, region of residence, pack-years of smoking, years of education, leisure-time exercise, body mass index, dietary intake of energy, cholesterol, vitamin E. alcohol, and coffee and the dietary glycemic index. The proportions of hypertension, hypercholesterolemia, and diabetes mellitus prior to the onset of PD were 23.7%, 9.6%, and 4.0%, respectively, in cases. Hypertension, hypercholesterolemia, and diabetes mellitus were significantly associated with a decreased risk of PD: the adjusted ORs were 0.43 (95% CI: 0.29-0.64), 0.58 (95% CI: 0.33-0.97), and 0.38 (95% CI: 0.17-0.79), respectively. No significant differences were observed in the association of vascular risk factors with the risk of PD between men and women. We found evidence of significant inverse associations of hypertension, hypercholesterolemia, and diabetes mellitus with the risk of PD in Japan. Further well-designed investigations of the association of vascular risk factors with the risk of PD are needed, particularly large-scale prospective studies in Asia. (C) 2010 Elsevier B.V. All rights reserved.