Distribution of PCBs and organochlorine pesticides in umbilical cord and maternal serum
Distribution of PCBs and organochlorine pesticides in umbilical cord and maternal serum
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DOI：
10.1016/s0048-9697(02)00167-5
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发表时间：
2002-10-21
影响因子：
9.8
通讯作者：
Schepens, R
中科院分区：
文献类型：
--
作者：
Covaci, A;Jorens, P;Schepens, R
多氯联苯（PCBs）和有机氯农药（如六氯苯（HCB）和1，1，1-三氯-2，2-二（4-氯苯基）乙烯（p，p '-DDE））是广泛存在于环境中的化合物，具有高度亲脂性，并在生物系统中积累。新生儿通过胎盘和母乳喂养接触这些有机氯化合物。这项研究报告了1999年11月至12月期间从比利时安特卫普市区44名妇女分娩时采集的产妇血液和脐带血样本中选定的多氯联苯同系物、p，p '-DDE和六氯苯的含量。结果表明，所有新生儿含有可检测水平的多氯联苯，p，p '-DDE和六氯苯。多氯联苯的中位浓度为450 pg/ml，范围在120和1580 pg/ml之间，而六氯苯和p，p '-DDE的中位浓度分别为70和490 pg/ml。脐血PCBs和p，p '-DDE浓度（ng/ml）与母血PCBs和p，p'-DDE浓度（ng/ml）呈正相关（相关系数分别为0.74和0.92，P < 0.05）。我们的结论是，所有调查的有机氯化合物有一个有效的经胎盘转移。(C)2002 Elsevier Science B. V.保留所有权利。
Polychlorinated biphenyls (PCBs) and organochlorine pesticides, such as, hexachlorobenzene (HCB) and 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethylene (p,p'-DDE) are compounds widespread in the environment, highly lipophilic, and accumulate in biological systems. The newborn are exposed to these organochlorine compounds across the placenta and through breastfeeding. This study reports the levels of selected PCB congeners, p,p'-DDE and HCB in maternal blood and cord blood samples collected at delivery between November and December 1999 from 44 women living in the urban area of Antwerp, Belgium. Results show that all newborns contained detectable levels of PCBs, p,p'-DDE and HCB. The median concentration of PCBs was 450 pg/ml and ranged between 120 and 1580 pg/ml, while the median concentrations of HCB and p,p'-DDE were 70 and 490 pg/ml, respectively. Concentrations of PCBs and p,p'-DDE in cord blood (ng/ml) were positively associated with concentrations' in matemal blood (ng/ml) (coefficients = 0.74 and 0.92, P < 0.05). We conclude that all investigated organochlorine compounds have an efficient transplacental transfer. (C) 2002 Elsevier Science B.V. All rights reserved.