Highly Regio-, Diastereo-, and Enantioselective Assembly of Azepino[2,3-b]indoles via Palladium-Catalyzed [4+3] Cycloaddition
Highly Regio-, Diastereo-, and Enantioselective Assembly of Azepino[2,3-b]indoles via Palladium-Catalyzed [4+3] Cycloaddition
复制标题
通过钯催化 [4 3] 环加成高度区域选择性、非对映选择性和对映选择性组装 Azepino[2,3-b]吲哚
DOI：
10.1002/cjoc.202000264
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发表时间：
2020
影响因子：
5.4
通讯作者：
Deng Wei-Ping
中科院分区：
文献类型：
--
作者：
Yang Wu-Lin;Huang Zesheng;Liu Yang-Zi;Yu Xingxin;Deng Wei-Ping
Summary of main observation and conclusionA palladium‐catalyzed asymmetric [4 + 3] cycloaddition of trimethylenemethanes and indoline‐derived aza‐dienes has been developed. The potential [3 + 2] side pathway was completely suppressed in the process. This protocol provides an efficient access to azepino[2,3‐b]indoles bearing two vicinal stereocenters in generally excellent diastereo‐ and enantioselectivities (up to > 20 : 1 dr, 99% ee).
