Independent differentiative pathways of Ly1 and Ly23 subclasses of T cells. Experimental production of mice deprived of selected T-cell subclasses
Independent differentiative pathways of Ly1 and Ly23 subclasses of T cells. Experimental production of mice deprived of selected T-cell subclasses
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T 细胞 Ly1 和 Ly23 亚类的独立分化途径。
DOI：
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发表时间：
1976
影响因子：
15.3
通讯作者：
E. Boyse
中科院分区：
文献类型：
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作者：
B. Huber;H. Cantor;F. Shen;E. Boyse
当给B小鼠提供Ly1或Ly23细胞时，在接下来的6个月里，它们分别只获得与这两种T细胞亚类相关的免疫功能。这些“B-Ly1”和“B-Ly23”小鼠的t细胞群也仍然局限于Ly1和Ly23亚类表型。因此，Ly1和Ly23群体来源于两条不同的分化线，而不是单一分化途径的连续阶段。
When B mice are supplied with Ly1 or Ly23 cells they acquire, over the next 6 mo, only the immune functions associated with each of these T- cell subclasses, respectively. The T-cell population of these "B-Ly1" and "B-Ly23" mice mice also remains restricted to the Ly1 and Ly23 subclass phenotypes. Thus the Ly1 and Ly23 populations are derived from two separate lines of differentiation and are not sequential stages of a single differentiative pathway.