Body mass index, triglycerides, glucose, and blood pressure as predictors of type 2 diabetes in a middle-aged Norwegian cohort of men and women.
Body mass index, triglycerides, glucose, and blood pressure as predictors of type 2 diabetes in a middle-aged Norwegian cohort of men and women.
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DOI：
10.2147/clep.s31830
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发表时间：
2012
影响因子：
3.9
通讯作者：
Strøm H
中科院分区：
文献类型：
--
作者：
Hjellvik V;Sakshaug S;Strøm H
肥胖、高血压和高甘油三酯血症是2型糖尿病的重要危险因素。我们想要评估与这三个因素单独和联合相关的风险，以及这些因素和其他几个危险因素(如非空腹血糖)作为T2D预测因素的相对重要性。在1995-1999年的健康研究中，对一名年龄在40-45岁的挪威人(n=109,796)的危险因素进行了测量。使用2004-2009年分发的降血糖药物来估计T2D的发生率。根据体重指数(BMI)、舒张压和甘油三酯的组合来定义男性和女性每个变量的50%和90%分位数。使用单变量和多变量Logistic回归模型的偏差来评估BMI、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、血糖、血压和出生年份对预测T2D的相对重要性。测量了身高、体重和血压。所有生物标志物都是在非空腹血样中测量的。在体重指数、甘油三酯和舒张压的不同组中，男性T2D的发生率从0.5%到19.7%，女性从0.15%到21.8%。体重指数是T2D事件的最强预测因子，其次是女性的甘油三酯水平和男性的血糖水平。在多变量模型中纳入BMI、血糖、甘油三酯和血压以外的危险因素只是略微改善了预测。体重指数是2型糖尿病的最强预测因子。在确定的BMI水平下，T2D的发生率与甘油三酯水平和血压有很大差异。因此，应该有针对性地控制中年人的甘油三酯和血压，以防止T2D的较晚发病。
Obesity, hypertension, and hypertriglyceridemia are important risk factors for type 2 diabetes (T2D). We wanted to assess the risk associated with these three factors alone and in combination, and the relative importance of these and several other risk factors (eg, nonfasting glucose) as predictors of T2D. Risk factors in a Norwegian population (n = 109,796) aged 40–45 years were measured in health studies in 1995–1999. Blood glucose-lowering drugs dispensed in 2004–2009 were used to estimate the incidence of T2D. Groups based on combinations of body mass index (BMI), diastolic blood pressure, and triglycerides were defined by using the 50% and 90% quantiles for each variable for men and women. The relative importance of BMI, triglycerides, total cholesterol, high-density lipoprotein cholesterol, glucose, blood pressure, and year of birth for predicting T2D was assessed using deviance from univariate and multivariate logistic regression models. Height, weight, and blood pressure were measured. All biomarkers were measured in nonfasting blood samples. In the various groups of BMI, triglycerides, and diastolic blood pressure, the incidence of T2D ranged from 0.5% to 19.7% in men and from 0.15% to 21.8% in women. BMI was the strongest predictor of incident T2D, followed by triglyceride levels in women and glucose levels in men. The inclusion of risk factors other than BMI, glucose, triglycerides, and blood pressure in multivariate models only marginally improved the prediction. BMI was the strongest predictor of type 2 diabetes. At defined levels of BMI, the incidence of T2D varied substantially with triglyceride levels and blood pressure. Thus, controlling triglycerides and blood pressure in middle-aged individuals should be targeted to prevent later onset of T2D.