Cerebral Asymmetry in Schizophrenia
Cerebral Asymmetry in Schizophrenia
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DOI：
10.1177/1073858410386493
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发表时间：
2011-10-01
期刊：
影响因子：
5.6
通讯作者：
Linden, David E. J.
中科院分区：
文献类型：
--
作者：
Oertel-Knoechell, Viola;Linden, David E. J.
人类大脑的两个半球在解剖学和功能上是不对称的，许多认知和运动功能，如语言和利手都是偏侧的。本文综述了解剖学，心理学和生理学的方法来理解单独的半球功能和它们的整合。大脑半球偏侧化的概念在精神分裂症的神经心理学和病理生理学模型中起着核心作用。大脑半球不对称性的减少也被报道用于其他精神疾病，例如双相情感障碍。最近的研究反映了对偏侧性的分子和群体遗传学及其与精神分裂症动物模型的潜在联系越来越感兴趣。作者回顾了偏侧性和大脑不对称性的原理，并讨论了精神分裂症和其他精神疾病不对称性变化的证据。
The hemispheres of the human brain are anatomically and functionally asymmetric, and many cognitive and motor functions such as language and handedness are lateralized. This review examines anatomical, psychological, and physiological approaches to the understanding of separate hemispheric functions and their integration. The concept of hemispheric laterality plays a central role in current neuropsychological and pathophysiological models of schizophrenia. Reduced hemispheric asymmetry has also been reported for other mental disorders, for example, bipolar disorder. Recent research reflects an increasing interest in the molecular and population genetics of laterality and its potential link with animal models of schizophrenia. The authors review the principles of laterality and brain asymmetry and discuss the evidence for changes in asymmetry in schizophrenia and other mental disorders.