APPLICATION OF THE QUAIL-CHICK CHIMERA SYSTEM TO THE STUDY OF BRAIN-DEVELOPMENT AND BEHAVIOR
APPLICATION OF THE QUAIL-CHICK CHIMERA SYSTEM TO THE STUDY OF BRAIN-DEVELOPMENT AND BEHAVIOR
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DOI：
10.1126/science.3413496
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发表时间：
1988-09-09
期刊：
影响因子：
56.9
通讯作者：
LEDOUARIN, N
中科院分区：
文献类型：
--
作者：
BALABAN, E;TEILLET, MA;LEDOUARIN, N
通过移植8- 15体节期神经管的不同部位，获得了具有家鸡（Gallus gallus arteriticus）和日本鹌鹑（Coturnix coturnix japonica）细胞嵌合脑的孵化雏鸡。宿主和供体细胞相对于移植物边界的位置在整个胚胎发育过程中观察到，孵化后牵连径向和切向细胞运动在脑形态发生。此外，含有整个鹌鹑中脑和间脑的移植导致了物种典型的啼叫行为的某些方面的转移。
Hatched chicks with chimeric brains containign cells from both the domestic chicken (Gallus gallus domesticus) and the Japanese quail (Coturnix coturnix japonica) have been produced by trnasplantation of various regions of the neural tube at the 8- to 15-somite stage. The positions of host and donor cells relative to graft boundaries observed throughout embryonic development and after hatching implicated both radial and tangential cell movements in brain morphogenesis. In addition, transplants containing the entire quail mesencephalon and diencephalon resulted in the transfer of certain aspects of species-typical crowing behavior.