Characterisation of antibacterial copper releasing degradable phosphate glass fibres
Characterisation of antibacterial copper releasing degradable phosphate glass fibres
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DOI：
10.1016/j.biomaterials.2004.07.024
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发表时间：
2005-05-01
期刊：
影响因子：
14
通讯作者：
Knowles, JC
中科院分区：
文献类型：
--
作者：
Abou Neel, EA;Ahmed, I;Knowles, JC
一般分子式na20 - cao - p2o5的磷酸盐基玻璃纤维（PGF）在水环境中可降解，因此可以通过包含铜等离子作为抗菌传递系统。在这项研究中，PGF与不同数量的氧化铜（CuO）被开发用于伤口愈合的潜在应用。制备了含有0、1、5和10mol% CuO的不同直径的PGF，并对其结构和抗菌性能进行了表征。采用快速差示扫描量热法、差示热法研究了CuO和纤维拉伸速度对玻璃性能的影响；分析和x射线衍射。研究了两种纤维直径对短期（3小时）附着和杀死金黄色葡萄球菌的影响，并研究了它们在去离子水中的降解率，以及使用离子色谱法测量铜离子释放。热分析表明，随着CuO含量的增加，PGF玻璃化转变温度显著升高。随着CuO含量的增加和纤维直径的增大，降解速率显著降低。在6 h以上，铜离子的释放量和速率随着CuO含量的增加而增加，纤维直径的减小从而增加了表面积体积比。附着在含氧化铜纤维上和周围环境中的活葡萄球菌数量都有所减少。(C) 2004 Elsevier Ltd.版权所有。
Phosphate-based glass fibres (PGF) of the general formula Na2O-CaO-P2O5 are degradable in an aqueous environment, and therefore can function as antibacterial delivery systems through the inclusion of ions such as copper. In this study, PGF with varying amounts of copper oxide (CuO) were developed for potential uses in wound healing applications. PGF with 0, 1, 5 and 10mol% CuO were produced with different diameters and characterised in terms of structural and antibacterial properties. The effect of CuO and fibre pulling speed on the glass properties were investigated using rapid differential scanning calorimetry, differential thermal; analysis and X-ray diffraction. The effect of two fibre diameters on short-term (3 h) attachment and killing against Staphylococcus opidermidis were investigated and were related to their rate of degradation in deionised water, as well as copper ion release measured using ion chromatography.Thermal analysis showed that there was a significant increase in the PGF glass transition temperature as the CuO content increased. There was a significant decrease in the rate of degradation with increasing CuO content and an increase in fibre diameter. Over 6 h, both the amount and rate of copper ions released increased with CuO content, as well as a reduction in fibre diameter thus increasing the surface area to volume ratio. There was a decrease in the number of viable staphylococci both attached to the CuO containing fibres and in the surrounding environment. (C) 2004 Elsevier Ltd. All rights reserved.