Coffee, green tea, and caffeine consumption and subsequent risk of bladder cancer in relation to smoking status: a prospective study in Japan
Coffee, green tea, and caffeine consumption and subsequent risk of bladder cancer in relation to smoking status: a prospective study in Japan
复制标题
DOI：
10.1111/j.1349-7006.2008.01027.x
复制
发表时间：
2009-02-01
期刊：
影响因子：
5.7
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
--
作者：
Kurahashi, Norie;Inoue, Manami;Tsugane, Shoichiro
咖啡和咖啡因的摄入被认为会增加患膀胱癌的风险。然而，很少有研究将这种风险与吸烟状况分层，这是一个潜在的混杂因素。在这里，我们调查了咖啡、绿茶（咖啡因的另一个主要来源）、咖啡因和膀胱癌发病率与吸烟状况之间的关系。我们在日本队列中进行了一项基于人群的前瞻性研究，包括49566名男性和54874名年龄在40-69岁之间的女性，他们报告了他们的咖啡和绿茶摄入量。在从1990年到2005年的随访中，164名男性和42名女性被新诊断为膀胱癌。吸烟与膀胱癌风险增加有关，且存在很强的剂量-反应关系。咖啡与男性膀胱癌风险呈正相关，但无统计学意义。当按吸烟状况分层时，咖啡和咖啡因的摄入量与从不吸烟或曾经吸烟的男性患膀胱癌的风险增加有关，最高类别的咖啡（每天一杯或多杯）和咖啡因的摄入量与最低类别的风险比（95%置信区间）分别为2.24 （95% CI = 1.21-4.16）和2.05 （95% CI = 1.15-3.66）。总之，吸烟是膀胱癌的一个危险因素。在从不吸烟或曾经吸烟的日本男性中，咖啡和咖啡因可能与膀胱癌风险增加有关。[j] .癌症科学，2009;100:284-291。
Coffee and caffeine consumption are thought to increase the risk of bladder cancer. However, few studies have stratified this risk by smoking status, which is a potential confounder. Here, we investigated the association between coffee, green tea (another major source of caffeine), and caffeine, and bladder cancer incidence in relation to smoking status. We conducted a population-based prospective study in a cohort of Japanese, comprising a total of 49 566 men and 54 874 women aged 40-69 years who reported their coffee and green tea consumption at baseline. During follow-up from 1990 through 2005, 164 men and 42 women were newly diagnosed with bladder cancer. Cigarette smoking was associated with an increased risk of bladder cancer, with a strong dose-response relationship. Coffee was positively associated with bladder cancer risk in men, without statistical significance. When stratified by smoking status, coffee and caffeine consumption were associated with an increased risk of bladder cancer in never- or former-smoking men, with hazard ratios (95% confidence interval) in the highest categories of coffee (one or more cups per day) and caffeine consumption compared with the lowest of 2.24 (95% CI = 1.21-4.16) and 2.05 (95% CI = 1.15-3.66), respectively. In conclusion, cigarette smoking was confirmed as a risk factor for bladder cancer. Coffee and caffeine may be associated with an increased bladder cancer risk in never or former smokers among Japanese men. (Cancer Sci 2009; 100: 284-291).