Alterations in methionine to homocysteine ratio in individuals with first-episode psychosis and those with at-risk mental state.
Alterations in methionine to homocysteine ratio in individuals with first-episode psychosis and those with at-risk mental state.
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首发精神病患者和精神状态处于危险状态的患者蛋氨酸与同型半胱氨酸比例的变化。
DOI：
10.1016/j.clinbiochem.2019.12.003
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Fukushima T
中科院分区：
文献类型：
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作者：
Onozato M;Uta A;Magarida A;Fukuoka N;Ichiba H;Tsujino N;Funatogawa T;Tagata H;Nemoto T;Mizuno M;Fukushima T
蛋氨酸（Met）循环是由同型半胱氨酸（Hcy）产生蛋氨酸的过程，其紊乱被认为与包括精神疾病在内的多种疾病有关。本研究旨在调查首发精神病（FEP）和高危精神状态（ARMS）患者血清中Met和Hcy的水平。方法采用高效液相色谱-荧光检测和LC-ESI-MS/MS联合检测FEP （n= 13）和ARMS （n= 30）患者血清Met和Hcy水平。健康对照（n= 41）也测量了Met和Hcy水平。采用Bonferroni校正的单因素方差分析（ANOVA）分析3组间的差异。结果FEP组血清Met水平降低（p =0.038）， Hcy水平升高（p =0.017）。与ARMS组相比，Hcy水平也显著升高（p =0.016），而Met水平在FEP组和ARMS组之间无显著差异。与对照组（p =4.58 × 10−4）和ARMS组（p =8.07 × 10−3）相比，FEP组Met/Hcy显著降低。此外，Met/Hcy比值与阳性和阴性综合征量表相关，尤其是阳性评分（p =5.90 × 10−5）。综上所述，血清Met/Hcy比值的降低可能是ARMS向FEP过渡期间发生精神病的危险因素，可能是ARMS向FEP过渡阶段的有用标志。
BackgroundDisturbance of the methionine (Met) cycle, which produces Met from homocysteine (Hcy), is suggested to be involved in several diseases, including psychiatric disorders. This study was aimed to investigate both levels of Met and Hcy in serum from individuals with first-episode psychosis (FEP) and individuals with at-risk mental state (ARMS).MethodWe measured serum Met and Hcy levels in individuals with FEP (n= 13) and ARMS (n= 30) using HPLC with fluorescence detection and LC-ESI-MS/MS. Met and Hcy levels in healthy controls (n= 41) were also measured. Differences between the 3 groups were analyzed by one-way analysis of variance (ANOVA) with Bonferroni correction.ResultsSerum Met levels were decreased (p =0.038) and Hcy levels were increased (p =0.017) in the FEP group. Hcy levels were also significantly increased compared to the ARMS group (p =0.016), while Met levels were not significantly different between the FEP and ARMS groups. A significant decrease in the Met to Hcy ratio (Met/Hcy) was observed in the FEP group compared to both the control (p =4.58 × 10−4) and ARMS (p =8.07 × 10−3) groups. Furthermore, Met/Hcy ratio was correlated with Positive and Negative Syndrome Scale, especially positive scores (p =5.90 × 10−5).ConclusionTaken together, these data indicate that a decrease in the serum Met/Hcy ratio may be a risk factor for developing psychosis during the transition from ARMS to FEP, and may prove to be a useful marker of the phase between ARMS and FEP.