Experimental validation of a spectroscopic gamma-ray detector based on a LaBr3 scintillator towards real-time dose monitoring in BNCT
Experimental validation of a spectroscopic gamma-ray detector based on a LaBr3 scintillator towards real-time dose monitoring in BNCT
复制标题
DOI：
10.1016/j.nima.2022.167409
复制
发表时间：
2022-09-11
影响因子：
1.4
通讯作者：
Fiorini, Carlo
中科院分区：
文献类型：
--
作者：
Caracciolo, Anita;Di Vita, Davide;Fiorini, Carlo
我们报道了基于LaBr3(Ce+Sr)闪烁晶体的探测模块的实验验证，该探测模块由硅光电倍增管(SiPM)矩阵读取，用于开发用于硼中子俘获治疗(BNCT)剂量监测的SPECT系统。该系统的目标是检测B-10(n，α)Li-7反应中产生的激发Li-7在478keV下发射的伽马射线，以便实时定位和量化在BNCT治疗期间释放给患者的局部剂量。探测器良好的能量分辨率(在662keV时为<；3%)允许从相邻的511keV的湮没光子中分辨出478keV的光峰，这些光峰源于高能伽马射线的产生，例如2.2 MeV的氢中子俘获伽马射线。本文的结果证明了我们的探测器在BNCT实时剂量监测中的应用前景。在478keV探测到的事件数与装载B-10样品的硼浓度之间实现了良好的线性(RMSE<；2.5cps)，低至62ppm的硼浓度，中子通量约为1×10(5)n/cm(2)/S。
We report the experimental validation of a detection module based on a LaBr3(Ce+Sr) scintillator crystal, read by a matrix of Silicon Photomultipliers (SiPMs), for the development of a SPECT system for dose monitoring in Boron Neutron Capture Therapy (BNCT). The goal of the system is to detect the gamma rays at 478 keV emitted by the excited Li-7 produced in the B-10(n, alpha)Li-7 reaction, to have a real-time localization and quantification of the local dose released to a patient during BNCT treatment. The good energy resolution of the detector (< 3% at 662 keV) allows to resolve the photopeak at 478 keV from the adjacent annihilation photons photopeak at 511 keV, originated from pair production of high energy gamma rays, such as the hydrogen neutron capture gamma rays at 2.2 MeV. The results shown in this article demonstrate the suitability of our detector in view of future application in BNCT real-time dose monitoring. Good linearity (RMSE < 2.5 cps) between the number of events detected at 478 keV and the boron concentration of the B-10-loaded samples has been achieved, down to a boron concentration of 62 ppm with a neutron flux of approximately 1 x 10(5) n/cm(2)/s.