Hybrid System for Simultaneous Fluorescence and X-Ray Computed Tomography
Hybrid System for Simultaneous Fluorescence and X-Ray Computed Tomography
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DOI：
10.1109/tmi.2009.2035310
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发表时间：
2010-02-01
影响因子：
10.6
通讯作者：
Ntziachristos, Vasilis
中科院分区：
文献类型：
--
作者：
Schulz, Ralf B.;Ale, Angelique;Ntziachristos, Vasilis
本文介绍了一种用于小动物荧光断层扫描和X射线计算机断层扫描（XCT）的混合成像系统。该系统利用了360度投影自由空间荧光断层摄影系统的成像能力，在微计算机断层摄影扫描仪内实现。图像采集基于自动调整一系列成像参数以提供高动态范围数据集的技术。图像分割进一步允许在光学重建问题中并入结构先验以改善成像性能。展示了功能系统的特点，并从大脑成像研究的图像显示，这是重建使用XCT衍生的先验到光学前向问题。
A hybrid imaging system for simultaneous fluorescence tomography and X-ray computed tomography (XCT) of small animals has been developed and presented. The system capitalizes on the imaging power of a 360 degrees-projection free-space fluorescence tomography system, implemented within a microcomputed tomography scanner. Image acquisition is based on techniques that automatically adjust a series of imaging parameters to offer a high dynamic range dataset. Image segmentation further allows the incorporation of structural priors in the optical reconstruction problem to improve the imaging performance. The functional system characteristics are showcased, and images from a brain imaging study are shown, which are reconstructed using XCT-derived priors into the optical forward problem.