Cancer as a metabolic disease: implications for novel therapeutics.
Cancer as a metabolic disease: implications for novel therapeutics.
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DOI：
10.1093/carcin/bgt480
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发表时间：
2014-03
期刊：
影响因子：
4.7
通讯作者：
D'Agostino DP
中科院分区：
文献类型：
--
作者：
Seyfried TN;Flores RE;Poff AM;D'Agostino DP
新出现的证据表明，癌症主要是一种代谢疾病，涉及通过呼吸和发酵产生能量的紊乱。在肿瘤细胞和所有其他公认的癌症特征中观察到的基因组不稳定性被认为是细胞能量代谢初始紊乱的下游副现象。肿瘤细胞能量代谢紊乱可能与线粒体结构和功能异常有关。当将拉马克的进化理论视为一种线粒体代谢疾病时，它比达尔文的进化理论更能解释癌症的进展。癌症的生长和进展可以在整个身体从发酵代谢物（主要是葡萄糖和谷氨酰胺）过渡到呼吸代谢物（主要是酮体）后得到控制。由于每个个体都是一个独特的代谢实体，作为一种基础广泛的癌症治疗策略的个性化代谢治疗将需要微调以使治疗与个体独特的生理相匹配。
Emerging evidence indicates that cancer is primarily a metabolic disease involving disturbances in energy production through respiration and fermentation. The genomic instability observed in tumor cells and all other recognized hallmarks of cancer are considered downstream epiphenomena of the initial disturbance of cellular energy metabolism. The disturbances in tumor cell energy metabolism can be linked to abnormalities in the structure and function of the mitochondria. When viewed as a mitochondrial metabolic disease, the evolutionary theory of Lamarck can better explain cancer progression than can the evolutionary theory of Darwin. Cancer growth and progression can be managed following a whole body transition from fermentable metabolites, primarily glucose and glutamine, to respiratory metabolites, primarily ketone bodies. As each individual is a unique metabolic entity, personalization of metabolic therapy as a broad-based cancer treatment strategy will require fine-tuning to match the therapy to an individual’s unique physiology.
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影响因子：
3.8
作者：
Baker, Stuart G.;Kramer, Barnett S.
通讯作者：
Kramer, Barnett S.
影响因子：
4.3
作者：
Bonuccelli, Gloria;Tsirigos, Aristotelis;Lisanti, Michael P.
通讯作者：
Lisanti, Michael P.
影响因子：
5.4
作者：
Bozidis, Petros;Williamson, Chad D.;Colberg-Poley, Anamaris M.
通讯作者：
Colberg-Poley, Anamaris M.
DOI：
10.1126/science.1226683
发表时间：
2012-12-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Al Mamun AA;Lombardo MJ;Shee C;Lisewski AM;Gonzalez C;Lin D;Nehring RB;Saint-Ruf C;Gibson JL;Frisch RL;Lichtarge O;Hastings PJ;Rosenberg SM
通讯作者：
Rosenberg SM
影响因子：
4.3
作者：
Baracca, Alessandra;Chiaradonna, Ferdinando;Lenaz, Giorgio
通讯作者：
Lenaz, Giorgio