The Quebec Pregnancy Cohort - Prevalence of Medication Use during Gestation and Pregnancy Outcomes
The Quebec Pregnancy Cohort - Prevalence of Medication Use during Gestation and Pregnancy Outcomes
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DOI：
10.1371/journal.pone.0093870
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发表时间：
2014-04-04
期刊：
影响因子：
3.7
通讯作者：
Sheehy, Odile
中科院分区：
文献类型：
--
作者：
Berard, Anick;Sheehy, Odile
目的：评价魁北克妊娠队列（QPC）作为围产期药物流行病学研究工具的潜力和有效性。方法：通过连接RAMQ（医疗和制药数据）、Med-Echo（住院数据）、ISQ（出生/死亡数据）和MELS（教育部数据）四个管理数据库构建质量计算模型。一份自行填写的调查问卷被随机发给一组女性样本，以收集她们的生活方式信息。QPC包括1998年至2008年魁北克省处方药保险涵盖的所有妇女怀孕的数据。进入QPC的日期是怀孕的第一天，在怀孕期间和怀孕后对妇女进行跟踪；孩子出生后一直被跟踪到2009年。比较怀孕前、怀孕期间和怀孕后处方药物的流行情况。对以活产婴儿结束的妊娠结局也进行了估计。结果：QPC包括186165名妇女的289688例妊娠。其中，167,398例分娩结束，占1998-2009年魁北克省所有分娩的19.4%。QPC的堕胎总频率为35.9%，而魁北克省的堕胎总频率为36.4%。孕前、孕中、产后处方用药率分别为74.6%、59.0%、79.6%。尽管在诊断出怀孕后，使用该药物的比例有统计学意义上的显著下降(p
Purpose: We evaluated the potential and the validity of the Quebec Pregnancy Cohort (QPC) as a research tool in perinatal pharmacoepidemiology.Methods: The QPC was built by linking four administrative databases: RAMQ (medical and pharmaceutical data), Med-Echo (hospitalizations), ISQ (births/deaths), and MELS (Ministry of Education data). A self-administered questionnaire was sent to a random sample of women to collect lifestyle information. The QPC includes data on all pregnancies of women covered by the Quebec provincial prescription drug insurance between 1998 and 2008. Date of entry in the QPC is the first day of pregnancy, and women are followed during and after pregnancy; children are followed after birth up until 2009. The prevalence of prescribed medications before, during and after pregnancy was compared between time-window. Pregnancy outcomes were also estimated among pregnancies ending with a live born infant.Results: The QPC included 289,688 pregnancies of 186,165 women. Among them, 167,398 ended with a delivery representing 19.4% of all deliveries occurring in the Province of Quebec between 1998-2009. The total frequency of abortions was 35.9% in the QPC comparable to the 36.4% observed in the Province of Quebec. The prevalence of prescribed medication use was 74.6%, 59.0%, and 79.6% before, during and after pregnancy, respectively. Although there was a statistically significant decrease in the proportion of use once the pregnancy was diagnosed (p