Palladium‐Catalyzed Coupling Reaction of Propargylic Oxiranes with Arylboronic Acids in Aqueous Media.
Palladium‐Catalyzed Coupling Reaction of Propargylic Oxiranes with Arylboronic Acids in Aqueous Media.
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DOI：
10.1002/chin.200601076
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发表时间：
2005-09
期刊：
影响因子：
--
通讯作者：
Masahiro Yoshida;H. Ueda;M. Ihara*
中科院分区：
文献类型：
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作者：
Masahiro Yoshida;H. Ueda;M. Ihara*
通过钯催化的炔丙基环氧乙烷与芳基硼酸的反应，开发了一种新型的偶联反应，其中以高度非对映选择性的方式生成反取代的 4-芳基-2,3-联烯醇。通过手性炔丙环氧乙烷的反应合成了手性取代的丙二烯，且不损失手性。
A novel type of coupling reaction has been developed by the palladium-catalyzed reaction of propargylic oxiranes with arylboronic acids, in which anti-substituted 4-aryl-2,3-allenols were produced in a highly diastereoselective manner. A chiral-substituted allene has been synthesized from the reaction of a chiral propargylic oxirane without loss of the chirality.