Tumor-targeted Drug Delivery by Nanocomposites
Tumor-targeted Drug Delivery by Nanocomposites
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DOI：
10.2174/1389200221666200520092333
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发表时间：
2020-01-01
影响因子：
2.3
通讯作者：
Khan, Mohd Sajid
中科院分区：
文献类型：
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作者：
Baker, Abu;Khan, Mohd Salman;Khan, Mohd Sajid
背景：肿瘤靶向给药纳米粒是一项巨大的成就，在非常低的剂量下使用高效的药物。传统的肿瘤靶向递送纳米颗粒的发展是基于增强的渗透性和滞留（EPR）效应，并且由于肿瘤的生物学和自然并发症以及对精确的纳米颗粒递送系统设计的限制，基于受体介导的内吞作用是非常苛刻的。不同的肿瘤环境刺激导致了用于肿瘤治疗和成像的触发多阶段药物递送系统（MSDDS）。MSDDS的物理化学性质，如大小、疏水性和潜在的转化，由于生理血液循环的不同，细胞内的肿瘤环境。该系统实现了药物穿透肿瘤、提高细胞摄取、精确定时释放药物以及内体释放。结果：MSDDS机制可使药物最大限度地释放到靶细胞、肿瘤组织和亚细胞生物体。难溶性化合物和生物利用度的问题已经面临的制药工业，这是解决纳米粒子formulation.Conclusion：在我们的审查中，我们说明了不同类型的触发情绪和刺激的肿瘤环境，这有助于智能多级药物输送系统的纳米粒子，基本上是一个多刺激敏感的输送系统，并阐述其功能，效果和诊断。
Background: Tumor-targeted delivery by nanoparticles is a great achievement towards the use of highly effective drug at very low doses. The conventional development of tumor-targeted delivery by nanoparticles is based on enhanced permeability and retention (EPR) effect and endocytosis based on receptor-mediated are very demanding due to the biological and natural complications of tumors as well as the restrictions on the design of the accurate nanoparticle delivery systems.Methods: Different tumor environment stimuli are responsible for triggered multistage drug delivery systems (MSDDS) for tumor therapy and imaging. Physicochemical properties, such as size, hydrophobicity and potential transform by MSDDS because of the physiological blood circulation different, intracellular tumor environment. This system accomplishes tumor penetration, cellular uptake improved, discharge of drugs on accurate time, and endosomal discharge.Results: Maximum drug delivery by MSDDS mechanism to target therapeutic cells and also tumor tissues and sub cellular organism. Poorly soluble compounds and bioavailability issues have been faced by pharmaceutical industries, which are resolved by nanoparticle formulation.Conclusion: In our review, we illustrate different types of triggered moods and stimuli of the tumor environment, which help in smart multistage drug delivery systems by nanoparticles, basically a multi-stimuli sensitive delivery system, and elaborate their function, effects, and diagnosis.