Impact of post-tuberculosis lung disease on health-related quality of life in patients from two tertiary hospitals in Lagos, Nigeria.
Impact of post-tuberculosis lung disease on health-related quality of life in patients from two tertiary hospitals in Lagos, Nigeria.
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DOI：
10.7196/ajtccm.2021.v27i2.135
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发表时间：
2021
影响因子：
--
通讯作者：
Adeyeye OO
中科院分区：
文献类型：
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作者：
Ozoh OB;Ojo OO;Dania MG;Dede SK;Adegboyega OA;Irurhe NK;Olowoyeye M;Adeyeye OO
结核病（TB）后肺部疾病是慢性呼吸道疾病的公认原因，其对健康相关生活质量（HRQoL）的影响尚未得到广泛描述。 描述在尼日利亚拉各斯两家三级医院就诊的患者的临床特征、肺功能损害和结核后肺部疾病对HRQoL的影响。 我们进行了一项横断面研究，并通过访谈，图表审查和身体检查获得数据。我们使用医学研究理事会（MRC）量表测量呼吸困难的严重程度，使用St乔治呼吸问卷（SGRQ）测量HRQoL，并进行肺量测定。采用单因素回归分析探讨所选变量与HRQoL之间的相关性。 共招募了59名参与者，他们的中位年龄（四分位距（IQR））为45（36 - 60）岁。最常见的症状是咳嗽（93.2%; n=55）和咳痰（91.5%; n=54）。不到三分之二的参与者（62.4%; n=38）接受过一次以上的TB治疗，50.8%（n=30）的参与者在MRC量表上有中度至极重度呼吸困难，88.7%（n=47/53）的参与者有肺功能异常，其中56.6%（n=30）的参与者以混合模式为主。症状的平均（标准差（SD））SGRQ组分评分为43.89（18.66），其次是活动（42.50（22.68））、影响（29.41（17.82））和总组分（35.78（17.25））。呼吸困难、咳嗽、咳痰和体重减轻与HRQoL恶化相关。 结核病后肺部疾病的特征是高症状负担、严重肺功能障碍和HRQoL差。有必要进一步认识和制定结核病后肺部疾病的诊断和治疗指南，并进一步研究探索预防战略。
Post-tuberculosis (TB) lung disease is a recognised cause of chronic respiratory disease, and its impact on health-related quality of life (HRQoL) has not been extensively described. To describe the clinical profile, spirometry impairment and impact of post-TB lung disease on HRQoL among patients attending two tertiary hospitals in Lagos, Nigeria. We conducted a cross-sectional study and obtained data through interviews, chart reviews and physical examination. We measured dyspnoea severity using the Medical Research Council (MRC) scale, HRQoL with the St George’s respiratory questionnaire (SGRQ) and performed spirometry. Univariate regression was used to explore the associations between selected variables and HRQoL. A total of 59 participants were recruited and their median (interquartile range (IQR)) age was 45 (36 - 60) years. The most frequent symptom was cough (93.2%; n=55) and sputum production (91.5%; n=54). Less than two-thirds of the participants (62.4%; n=38) had received treatment for TB on more than one occasion, 50.8% (n=30) had moderate to very severe dyspnoea on the MRC scale and 88.7% (n=47/53) had abnormal spirometry with the mixed pattern predominating in 56.6% (n=30) of the participants. The mean (standard deviation (SD)) SGRQ component score for symptoms was 43.89 (18.66), followed by activity (42.50 (22.68)), impact (29.41 (17.82)) and total components (35.78 (17.25)). Dyspnoea, cough, sputum production and weight loss were associated with worsened HRQoL. Post-TB lung disease was characterised by a high symptom burden, severe spirometry impairment and poor HRQoL. There is a need for increased recognition and development of guidelines for diagnosis and treatment of post-TB lung disease and for further studies to explore preventive strategies.