Epidemiologic evidence for uterine growth factors in the pathogenesis of ovarian cancer
Epidemiologic evidence for uterine growth factors in the pathogenesis of ovarian cancer
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DOI：
10.1016/1047-2797(94)00098-e
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发表时间：
1995-01-01
影响因子：
5.6
通讯作者：
Xu, Huijuan
中科院分区：
文献类型：
--
作者：
Cramer, Daniel W.;Xu, Huijuan
为了根据不同的解释来检查卵巢癌与既往子宫切除术或输卵管结扎术之间的关联，我们结合了之前进行的两项卵巢癌病例对照研究的数据。这包括 450 名经组织学证实患有上皮性卵巢癌的女性和 454 名来自普通人群的年龄匹配的女性，她们之前的盆腔手术数据可用于估计暴露比值比。总体而言，接受子宫切除术或输卵管结扎术的病例患者存在不显着的缺陷（比值比 (OR) = 0.9；95% 置信区间 (CI)，0.6 至 1.3）。对于 20 年前接受过子宫切除术或输卵管结扎术的女性（OR = 0.6；95% CI，0.3 至 1.1）、未在卫生中使用滑石粉的女性（OR = 0.6；95% CI，0.4 至 1.0）以及患有卵巢粘液性肿瘤的女性（OR = 0.3；95% CI， 0.1 至 1.0）。尽管这些数据没有明确确定既往盆腔手术与卵巢癌之间关联的有效性或机制，但我们推测这种关联存在，并且可能是通过子宫生长因子缺失或减少介导的，这些因子通过子宫卵巢循环到达卵巢，而粘液性肿瘤最依赖于这些因素。
To examine the association between ovarian cancer and prior hysterectomy or tubal ligation in light of various interpretations, we combined data from two previously conducted case-control studies of ovarian cancer. This included 450 women with histologically verified epithelial ovarian cancer and 454 age-matched women from the general population of whom data on prior pelvic surgery were available to estimate exposure odds ratios. Overall there was a nonsignificant deficit of case patients who had had a hysterectomy or tubal ligation (odds ratio (OR) = 0.9; 95% confidence interval (CI), 0.6 to 1.3). A protective effect of prior hysterectomy or tubal ligation was more apparent among women who had the surgery 20 or more years previously (OR = 0.6; 95% CI, 0.3 to 1.1), women who had not used talc in their hygiene (OR = 0.6; 95% CI, 0.4 to 1.0), and women with mucinous tumors of the ovary (OR = 0.3; 95% CI, 0.1 to 1.0). Although these data do not clearly establish the validity of or mechanisms for an association between prior pelvic surgery and ovarian cancer, we speculate that such an association exists and may be mediated through absent or reduced uterine growth factors that reach the ovaries through the uteroovarian circulation, with mucinous tumors most dependent on such factors.