Effects of inter-α-inhibitor in experimental endotoxic shock and disseminated intravascular coagulation
Effects of inter-α-inhibitor in experimental endotoxic shock and disseminated intravascular coagulation
复制标题
α间抑制剂对实验性内毒素休克和弥散性血管内凝血的影响
DOI：
10.1164/ajrccm.156.6.9611100
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发表时间：
1997
影响因子：
24.7
通讯作者：
C. Chopin
中科院分区：
文献类型：
--
作者：
M. Jourdain;O. Carrette;A. Tournoys;F. Fourrier;C. Mizon;J. Mangalaboyi;J. Goudemand;J. Mizon;C. Chopin
We investigated the effects of human inter- α -inhibitor (I α I) on hemodynamics, oxygenation, and coagulation parameters in a porcine model of endotoxic shock. Four groups of six animals were studied: (1) control, (2) I α I group receiving 30 mg/kg I α I over 30 min, (3) LPS group receiving 5 μ g · kg/min Escherichia coli endotoxin over 30 min, and (4) LPS + I α I group receiving 30 min after endotoxin 30 mg/kg/30 min I α I. We measured hemodynamic and oxygenation parameters, usual coagulation markers and plasma levels of thrombin-antithrombin complexes, antithrombin III activity, plasminogen activator tissue type, plasminogen activator inhibitor type 1, von Willebrand factor, tumor necrosis factor- α , and I α I at baseline and at 30, 60, 90, 120, 180, 240, and 300 min. In the I α I group, plasma I α I levels reached 447 ± 23 mg/L just after injection and 287 ± 39 mg/L at 300 min. I α I half-life was 7.3 ± 1.9 h. In the LPS + I α I group, I α I plasma levels decreased more rapidly, reaching 260 mg/L at ...
影响因子：
4.4
作者：
H. Wisniewski;J. Hua;D. Poppers;Dwight Naime;J. Vilček;B. Cronstein
通讯作者：
H. Wisniewski;J. Hua;D. Poppers;Dwight Naime;J. Vilček;B. Cronstein
影响因子：
158.5
作者：
SUFFREDINI, AF;HARPEL, PC;PARRILLO, JE
通讯作者：
PARRILLO, JE