Electrical conditioning of in situ skeletal muscle for replacement of myocardium.
Electrical conditioning of in situ skeletal muscle for replacement of myocardium.
复制标题
原位骨骼肌的电调节以替代心肌。
DOI：
10.1016/0022-4804(82)90123-8
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
L. Edmunds
中科院分区：
文献类型：
--
作者：
J. Macoviak;Larry W. Stephenson;F. Armenti;A. Kelly;Abass Alavi;T. Mackler;J. Cox;G. Palatianos;L. Edmunds
以2Hz（N= 3）和10Hz（N= 5）电刺激8只犬右半膈，持续135天。ATP酶组织化学研究表明，几乎全部的转换II型快缩疲劳肌纤维的I型慢缩疲劳抵抗肌纤维。受刺激肌肉的厚度和血管灌注显著增加。电阈值保持不变。在10 Hz刺激下，肌肉剧烈收缩，长达135天无疲劳。以10 Hz频率对犬膈肌骨骼肌进行5周的电调节，导致95%和更高的抗慢颤疲劳肌纤维群体。骨骼肌的这种变化使其成为更适合的自体移植物，用于置换或增强病变心肌。
Eight canine right hemidiaphragms were electrically stimulated at 2Hz (N= 3) and 10 Hz (N= 5) for up to 135 days. ATPase histochemical studies showed nearly total transformation of type II fast twitch fatigable muscle fibers to type I slow twitch fatigue resistant muscle fibers. The thickness and vascular perfusion of the stimulated muscle increased significantly. Electrical thresholds remained unchanged. The muscle contracted vigorously and without fatigue for up to 135 days at 10 Hz stimulation. Electrical conditioning of canine diaphragm skeletal muscle at 10 Hz frequency for 5 weeks results in a 95% and greater population of slow twitch fatigue resistant muscle fibers. This change in diaphragmatic skeletal muscle should make it a more suitable autograft for replacement or augmentation of diseased cardiac muscle.