Thalamic amnesia reconsidered:: Excitotoxic lesions of the intralaminar nuclei, but not the mediodorsal nucleus, disrupt place delayed matching-to-sample performance in rats (Rattus norvegicus)
Thalamic amnesia reconsidered:: Excitotoxic lesions of the intralaminar nuclei, but not the mediodorsal nucleus, disrupt place delayed matching-to-sample performance in rats (Rattus norvegicus)
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DOI：
10.1037/0735-7044.112.1.54
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发表时间：
1998-02-01
影响因子：
1.9
通讯作者：
Mair, RG
中科院分区：
文献类型：
--
作者：
Burk, JA;Mair, RG
影响内侧背核（MDn）和板内核（ILn）的大丘脑病变的大鼠在执行延迟匹配样本任务（DMTS）时受损。为了确定这种缺陷的神经基础，我们训练大鼠进行一个地方DMTS任务，然后比较MDn，ILn和外侧内髓板（L-IML）的兴奋性毒性病变的影响。MDn病变几乎没有影响。ILn组在8个月的训练中明显受损。L-IML组表现出中等程度的损伤。不同的样品响应要求，保留时间间隔，并在侧加强审判一致性，预测的影响，在响应潜伏期的变化。然而，这些因素都没有与治疗效果相互作用。这些发现表明，DMTS性能被破坏的病变的ILn，但不是MDn。
Rats with large thalamic lesions affecting the mediodorsal (MDn) and intralaminar (ILn) nuclei are impaired performing delayed matching to sample tasks (DMTS). To determine the neurological basis of this deficit, we trained rats to perform a place DMTS task and then compared the effects of excitotoxic lesions of the MDn, the ILn, and the lateral internal medullary lamina (L-IML). The MDn lesion had little effect. The ILn group was significantly impaired throughout 8 months of training. The L-IML group exhibited an intermediate level of impairment. Varying the sample response requirement, retention intervals, and trial-to-trial congruence in the side reinforced, had predicted effects, as did variations in response latency. However, none of these factors interacted with the treatment effects. These findings indicate that DMTS performance is disrupted by lesions of the ILn but not the MDn.