Evoked effective connectivity of the human neocortex.
Evoked effective connectivity of the human neocortex.
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DOI：
10.1002/hbm.22581
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发表时间：
2014-12
影响因子：
4.8
通讯作者：
Mehta AD
中科院分区：
文献类型：
--
作者：
Entz L;Tóth E;Keller CJ;Bickel S;Groppe DM;Fabó D;Kozák LR;Erőss L;Ulbert I;Mehta AD
皮层连通性在脑功能和病理中的作用越来越被认识到。虽然体内磁共振成像研究为解剖和功能连接提供了重要的见解，但这些方法在检测电生理活动和有效连接背后的因果关系方面的能力有限。在这里，我们描述了使用单脉冲电刺激对25例患者进行硬脑膜下电极阵列监测癫痫发作的皮质-皮质诱发电位（CCEP）映射的结果。通过刺激相邻电极对并记录来自电极阵列剩余部分的ccep来进行映射。ccep可靠地揭示了功能网络，并与位点之间的距离呈反比关系。共登记到Brodmann区域（BA）允许组分析。连接通常具有方向性，43%的早期响应和50%的晚期响应反映了传入或传出连接的相对优势。最一致的连接来自运动皮层、BA6-BA9、体感皮层、前扣带皮层和布洛卡区。网络拓扑显示，运动、SS和运动前皮层以及BA9和BA10和语言区作为皮层连接的枢纽。BA20和BA39表现出最一致的外度连接优势，而BA5、BA7、听觉皮层和前扣带表现出相对较大的程度。这项多中心、大规模、定向的局部和远程皮质连通性研究使用清醒时的直接记录，将有助于解释非侵入性功能连接组研究。
The role of cortical connectivity in brain function and pathology is increasingly being recognized. While in vivo magnetic resonance imaging studies have provided important insights into anatomical and functional connectivity, these methodologies are limited in their ability to detect electrophysiological activity and the causal relationships that underlie effective connectivity. Here, we describe results of cortico-cortical evoked potential (CCEP) mapping using single pulse electrical stimulation in 25 patients undergoing seizure monitoring with subdural electrode arrays. Mapping was performed by stimulating adjacent electrode pairs and recording CCEPs from the remainder of the electrode array. CCEPs reliably revealed functional networks and showed an inverse relationship to distance between sites. Coregistration to Brodmann areas (BA) permitted group analysis. Connections were frequently directional with 43% of early responses and 50% of late responses of connections reflecting relative dominance of incoming or outgoing connections. The most consistent connections were seen as outgoing from motor cortex, BA6–BA9, somatosensory (SS) cortex, anterior cingulate cortex, and Broca's area. Network topology revealed motor, SS, and premotor cortices along with BA9 and BA10 and language areas to serve as hubs for cortical connections. BA20 and BA39 demonstrated the most consistent dominance of outdegree connections, while BA5, BA7, auditory cortex, and anterior cingulum demonstrated relatively greater indegree. This multicenter, large-scale, directional study of local and long-range cortical connectivity using direct recordings from awake, humans will aid the interpretation of noninvasive functional connectome studies.