Role of Ikaros in T-cell acute lymphoblastic leukemia.
Role of Ikaros in T-cell acute lymphoblastic leukemia.
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DOI：
10.4331/wjbc.v2.i6.108
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发表时间：
2011-06-26
期刊：
影响因子：
--
通讯作者：
Chan, Susan
中科院分区：
文献类型：
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作者：
Kastner, Philippe;Chan, Susan
Ikaros是由Ikzf1基因编码的锌指转录调节因子。Ikaros在造血系统中显示出至关重要的功能，其功能的丧失与淋巴性白血病的发展有关。特别是，近年来发现Ikaros是参与人类b细胞急性淋巴细胞白血病的主要肿瘤抑制因子。然而，它在t细胞白血病中的作用更有争议。虽然Ikaros缺乏在小鼠t细胞白血病中似乎非常常见，但Ikaros缺失在人类t细胞急性淋巴细胞白血病（T-ALL）中似乎很少见。我们在这里回顾了Ikaros与小鼠和人类系统中T-ALL相关的证据。
Ikaros is a zinc finger transcriptional regulator encoded by the Ikzf1 gene. Ikaros displays crucial functions in the hematopoietic system and its loss of function has been linked to the development of lymphoid leukemia. In particular, Ikaros has been found in recent years to be a major tumor suppressor involved in human B-cell acute lymphoblastic leukemia. Its role in T-cell leukemia, however, has been more controversial. While Ikaros deficiency appears to be very frequent in murine T-cell leukemias, loss of Ikaros appears to be rare in human T-cell acute lymphoblastic leukemia (T-ALL). We review here the evidence linking Ikaros to T-ALL in mouse and human systems.