INDUCTION OF UPPER AIRWAY OCCLUSION IN SLEEPING INDIVIDUALS WITH SUBATMOSPHERIC NASAL PRESSURE
INDUCTION OF UPPER AIRWAY OCCLUSION IN SLEEPING INDIVIDUALS WITH SUBATMOSPHERIC NASAL PRESSURE
复制标题
DOI：
10.1152/jappl.1988.64.2.535
复制
发表时间：
1988-02-01
影响因子：
3.3
通讯作者：
PERMUTT, S
中科院分区：
文献类型：
--
作者：
SCHWARTZ, AR;SMITH, PL;PERMUTT, S
在可收缩的生物导管中，当上游压力福尔斯下降到临界压力（Pcrit）以下时，发生流动的阻塞和停止。为了研究Pcrit与上气道阻塞发展之间的关系，我们研究了7名正常受试者睡眠期间最大吸气流量与鼻压之间的关系。在非快速眼动（NREM）睡眠期间，在不同的负压水平下，鼻罩上的最大吸气气流与鼻压水平成比例下降。当鼻压下降到Pcrit以下时，受试者表现出上呼吸道阻塞，由唤醒终止。在这些正常受试者中，发现上呼吸道Pcrit为-13.3 ±。3.2（SD）cmH2O。在4例持续睡眠而鼻压保持低于Pcrit的受试者中，证实了复发性阻塞性呼吸暂停。通过线性回归拟合每个受试者的最大吸气气流和鼻压之间的关系，并证明零流量截距处的上气道Pcrit与实验观察到的无显著差异。这些数据表明，正常人的上呼吸道在睡眠期间的特征在于负Pcrit和阻塞时，鼻压降低到低于此Pcrit可能会引起。
In collapsible biologic conduits, occlusion and cessation of flow occur when upstream pressure falls below a critical pressure (Pcrit). To examine the relationship between Pcrit and the development of upper airway occlusion, we examined the relationship between maximal inspiratory airflow and nasal pressure in seven normal subjects during sleep. At varying levels of subatmospheric pressure applied to a nasal mask during non-rapid-eye-movement (NREM) sleep, maximal inspiratory airflow decreased in proportion to the level of nasal pressure. When nasal pressure fell below a Pcrit, subjects demonstrated upper airway occlusions terminated by arousals. In these normal subjects, the upper airway Pcrit was found to be -13.3 .+-. 3.2 (SD) cmH2O. In four subjects who sustained sleep while nasal pressure remained below the Pcrit, recurrent occlusive apneas were demonstrated. The relationship between maximal inspiratory airflow and nasal pressure in each subject was fit by linear regression and demonstrated upper airway Pcrit at the zero-flow intercept that were not significantly different from those observed experimentally. These data demonstrate that the normal human upper airway during sleep is characterized by a negative Pcrit and that occlusion may be induced when nasal pressure is decreased below this Pcrit.