Cystic fibrosis:: inflammatory response to infection with Burkholderia cepacia and Pseudomonas aeruginosa
Cystic fibrosis:: inflammatory response to infection with Burkholderia cepacia and Pseudomonas aeruginosa
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DOI：
10.1034/j.1399-3003.1999.14b32.x
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发表时间：
1999-08-01
影响因子：
24.3
通讯作者：
Webb, AK
中科院分区：
文献类型：
--
作者：
Hendry, J;Elborn, JS;Webb, AK
囊性纤维化（CF）中洋葱伯克霍尔德菌的肺定植可能与肺功能恶化有关。这可能是由于宿主炎症反应比铜绿假单胞菌定植时更强烈，导致更大的肺损伤。在一项为期18个月的前瞻性研究中，在感染加重和临床稳定期对患有CF的成年人进行了循环炎症标志物测定。I！铜绿假单胞菌（n=41）。B。洋葱（n=13）和成人谁间歇增长B。三组患者的炎症标志物水平无显著性差异（P> 0.05）。铜绿假单胞菌B. aeruginosa，B.洋葱B. cepacia，B.间歇性洋葱病）。当临床稳定时，所有组中的炎症标志物水平与匹配的非CF人群相比均升高，表明持续炎症和感染加重之间肺损伤的可能性。本研究不支持肺定植与铜绿假单胞菌定植相比与炎症反应升高相关的假设。
Pulmonary colonization by Burkholderia cepacia in cystic fibrosis (CF) may be associated,vith enhanced deterioration of pulmonary function. This may be due to a more florid host inflammatory response than in colonization by Pseudomonas aeruginosa, leading to greater lung injury.Circulating markers of inflammation were determined during infective exacerbations and periods of clinical stability in an 18 month prospective study in adults with CF colonized by I! aeruginosa (n=41). B. cepacia (n=13) and in adults who intermittently grew B. cepacia (n=6).There were no differences between the levels of the inflammation markers measured in the three groups (P! aeruginosa, B. cepacia, B. cepacia intermittent) at any of the assessment points. When clinically stable, levels of inflammatory markers in all groups were elevated compared to a matched non-CF population, indicating, continuous inflammation and the potential for lung damage between infective exacerbations.This study does not support the hypothesis that pulmonary colonization,vith Burkholderia cepacia is associated with a heightened inflammatory response compared,vith Pseudomonas aeruginosa colonization.