THE EFFECT ON REGIONAL LUNG DEPOSITION OF COUPLED HEAT AND MASS-TRANSFER BETWEEN HYGROSCOPIC DROPLETS AND THEIR SURROUNDING PHASE
THE EFFECT ON REGIONAL LUNG DEPOSITION OF COUPLED HEAT AND MASS-TRANSFER BETWEEN HYGROSCOPIC DROPLETS AND THEIR SURROUNDING PHASE
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DOI：
10.1016/0021-8502(94)00132-i
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发表时间：
1995-06-01
影响因子：
4.5
通讯作者：
STAPLETON, KW
中科院分区：
文献类型：
--
作者：
FINLAY, WH;STAPLETON, KW
描述了用于耦合吸入气溶胶液滴和携带液滴的连续相之间的热质传递的程序，并将其并入吸湿的人肺沉积模型中。 在气道壁处的热质传递系数被用来解释耦合对壁热质传递的影响。 在50%环境RH、20 ℃和典型的吸入和雾化器流速下，到目前为止，耦合的最大影响是对胸外剂量的影响，对于初始等渗的2.5 mum MMAD（GSD 1.7）和6.0 mum MMAD（GSD 1.7）气溶胶，其分别比没有耦合的预测值高出137%和50%，其中10（6）个液滴cm-3。 偶联通过以下方式影响剂量：
A procedure for coupling the heat and mass transfer between inhaled aerosol droplets and the continuous phase that carries the droplets is described and incorporated into a hygroscopic human lung deposition model. Heat and mass transfer coefficients at the airway walls are used to account for the effect of the coupling on wall heat and mass transfer. At 50% ambient RH, 20-degrees-C, and typical inhalation and nebulizer flow rates, by far the largest effect of coupling is on extrathoracic dosages, which are up to 137% and 50% greater than that predicted without coupling for initially isotonic 2.5 mum MMAD (GSD 1.7) and 6.0 mum MMAD (GSD 1.7) aerosols respectively, with 10(6) droplets cm-3. Coupling affects dosages by