LUBRICATION OF SYNOVIAL MEMBRANE
LUBRICATION OF SYNOVIAL MEMBRANE
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DOI：
10.1136/ard.30.3.322
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发表时间：
1971-01-01
影响因子：
27.4
通讯作者：
SCHOTTSTAEDT, ES
中科院分区：
文献类型：
--
作者：
RADIN, EL;PAUL, IL;SCHOTTSTAEDT, ES
关节僵硬是关节炎疾病患者的重要临床表现。大多数关节的关节表面区域在很大程度上是滑膜组织。软骨间的摩擦力极低，关节运动的大部分阻力来自滑膜上的关节囊、韧带、肌腱和皮肤（Smith，1956；Johns 和 Wright，1962；Barnett 和 Cobbold，1969）。尽管已经对关节炎和年龄引起的僵硬类型和数量进行了分析（Barnett 和 Cobbold，1968；Wright、Dowson 和 Longfield，1969），但尚未研究滑膜对滑膜或滑膜对软骨运动实际涉及的润滑机制。这些研究对于解释润滑剂粘度在关节功能中的可能作用也可能具有重要价值。滑液具有典型的粘性，但由于这种粘性并不是软骨间润滑的主要决定因素（McCutchen，1962；Linn，1968），因此有人认为润滑剂粘性很可能在滑膜组织的光滑性中发挥重要作用（McCutchen，1969）。由于这些原因，我们对滑膜润滑进行了研究，并在此进行了报道。 方法滑膜组织取自 3 至 4 岁健康牛的膝关节。首先检查膝盖以确保没有关节炎变化。切下约 3 x 3 厘米的方形滑膜片及其附着的囊，在等渗缓冲液中清洗，将滑膜面朝下放置在电机驱动的抛光玻璃滑块上，并通过细丝线连接到力传感器（Statham Instruments，Inc.，洛杉矶，加利福尼亚州）（图）。软骨在玻璃上摩擦有摩擦力
Joint stiffness is a significant clinical manifestation of patients with arthritic disease. The articulating surface area of most joints is to a great extent synovial tissue. Cartilage-on-cartilage friction is extremely low and most of the resistance to joint motion is from the capsule, ligaments, tendons, and skin which'ricde'over the joint on synovium (Smith, 1956; Johns and Wright, 1962; Barnett and Cobbold, 1969). Although analyses have been made of the types and amounts of stiffness encountered with arthritis and age (Barnett and Cobbold, 1968; Wright, Dowson, and Longfield, 1969), there have been no studies of the lubrication mechanisms actually involved in synovium on synovium or synovium on cartilage motion. Such studies might also be of great value in explaining the possible role of lubricant viscosity in joint function. Synovial fluid is characteristically viscous, but since this viscosity is not the prin, ary determining factor in cartilage-on-cartilage lubrication (McCutchen, 1962; Linn, 1968), it has been suggested that lubricant viscosity might well be playing a significant role in synovial tissue slipperi-ness (McCutchen, 1969). For these reasons an investigation of synovial membrane lubrication was undertaken and is reported here.Methed Synovial tissue was obtained from the knee joints of healthy cows, aged 3 to 4 years. The knees were first inspected to insure freedom from arthritic change. Square pieces of synovium, about 3 x 3 cm., with their attached capsule, were cut, washed in isotonic buffer, placed synovial side down on a motor-driven polished glass slider, and attached to a force transducer (Statham Instruments, Inc., Los Angeles, California) by a thin silk thread (Figure). Cartilage rubbing on glass has frictional