Neuronal activation in the human centromedian-parafascicular complex predicts cortical responses to behaviorally significant auditory events
Neuronal activation in the human centromedian-parafascicular complex predicts cortical responses to behaviorally significant auditory events
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DOI：
10.1016/j.neuroimage.2020.116583
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发表时间：
2020-05-01
期刊：
影响因子：
5.7
通讯作者：
Krauss, Joachim K.
中科院分区：
文献类型：
--
作者：
Beck, Anne-Kathrin;Sandmann, Pascale;Krauss, Joachim K.
对非人类灵长类动物的研究表明，丘脑对大脑皮层有兴奋性影响，其中中央-旁束复合体（CM-PO）特别参与感觉事件驱动的注意和唤醒过程。为了确定人类CM-Pf参与自下而上和自上而下的听觉注意，我们通过植入用于治疗神经性疼痛的脑深部刺激的电极同时记录了皮层EEG活动和颅内局部场电位（LFP）。患者（N = 6）进行了听觉三级oddball范式与频繁的标准刺激和两种类型的不常见的偏离刺激（目标和分心）。我们发现了顶叶P3 b的目标和中央P3 a的分心物在头皮水平。CM-Pf的皮层下记录显示，与标准相比，对目标的激活增强。间相关分析表明，激活CM-Pf预测产生更长的潜伏期P3 b头皮电位，特别是在目标条件。我们的研究结果提供了第一个直接的人类证据的目标相关的激活在CM-Pf和增强的皮质目标响应之间的功能时间关系。这些结果证实了假设模型的皮质基底神经节环路系统，开关从自上而下到自下而上的模式，在响应显着的，任务相关的外部事件是不可预测的。
Studies with non-human primates have suggested an excitatory influence of the thalamus on the cerebral cortex, with the centromedian-parafascicular complex (CM-PO being particularly involved in processes of sensory event-driven attention and arousal. To define the involvement of the human CM-Pf in bottom-up and top-down auditory attention, we simultaneously recorded cortical EEG activity and intracranial local field potentials (LFPs) via electrodes implanted for deep brain stimulation for the treatment of neuropathic pain. The patients (N = 6) performed an auditory three-class oddball paradigm with frequent standard stimuli and two types of infrequent deviant stimuli (target and distractor). We found a parietal P3b to targets and a central P3a to distractors at the scalp level. Subcortical recordings in the CM-Pf revealed enhanced activation to targets compared to standards. Interarea-correlation analyses showed that activation in the CM-Pf predicted the generation of longer latency P3b scalp potentials specifically in the target condition. Our results provide first direct human evidence for a functional temporal relationship between target-related activation in the CM-Pf and an enhanced cortical target response. These results corroborate the hypothetical model of a cortico-basal ganglia loop system that switches from top-down to bottom-up mode in response to salient, task-relevant external events that are not predictable.