Association of the Functional MICA-129 Polymorphism With the Severity of Chronic Chagas Heart Disease.
Association of the Functional MICA-129 Polymorphism With the Severity of Chronic Chagas Heart Disease.
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DOI：
10.1093/cid/civ540
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发表时间：
2015-10-15
期刊：
影响因子：
--
通讯作者：
Mattos LC
中科院分区：
文献类型：
--
作者：
Ayo CM;Oliveira AP;Camargo AV;Mattos CC;Bestetti RB;Mattos LC
云母-129多态性影响云母分子与NKG 2D受体的结合亲和力，并影响效应细胞功能。met/met基因型与慢性恰加斯心脏病患者左心室收缩功能障碍（LVSD）的严重程度相关，而瓦尔/瓦尔基因型与无LVSD相关。
MICA-129 polymorphism affects the binding affinity of MICA molecules with the NKG2D receptor and influences effector cell function. The genotype met/met was associated with the severity of left ventricular systolic dysfunction (LVSD) in patients with chronic Chagas heart disease, while the val/val genotype was associated with the absence of LVSD.