Sodium Fluoride-18 and Radium-223 Dichloride Uptake Colocalize in Osteoblastic Mouse Xenograft Tumors.
Sodium Fluoride-18 and Radium-223 Dichloride Uptake Colocalize in Osteoblastic Mouse Xenograft Tumors.
复制标题
氟化钠 18 和镭 223 二氯化物摄取在成骨细胞小鼠异种移植肿瘤中共定位。
DOI：
10.1089/cbr.2020.4068
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发表时间：
2021
影响因子：
3.4
通讯作者：
Jagoda,ElaineM
中科院分区：
文献类型：
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作者：
Phelps,TimE;Roy,Jyoti;Green,MichaelV;Seidel,Jurgen;Baidoo,KwamenaE;Adler,Stephen;Edmondson,ElijahF;Butcher,Donna;Matta,JenniferL;Ton,AnitaT;Wong,Karen;Huang,Shan;Ren,Ling;LeBlanc,AmyK;Choyke,PeterL;Jagoda,ElaineM
Background:Patients with osteoblastic bone metastases are candidates for radium-223 (223RaCl2) therapy and may undergo sodium fluoride-18 (18F-NaF) positron emission tomography-computed tomography imaging to identify bone lesions.18F-NaF has been shown to predict223RaCl2uptake, but intratumor distributions of these two agents remain unclear. In this study, the authors evaluate the spatial distribution and relative uptakes of18F-NaF and223RaCl2in Hu09-H3 human osteosarcoma mouse xenograft tumors at macroscopic and microscopic levels to better quantify their correlation.Materials and Methods:18F-NaF and223RaCl2were co-injected into Hu09-H3 xenograft tumor severe combined immunodeficient mice. Tumor content was determined fromin vivobiodistributions and visualized by PET, single photon emission computed tomography, and CT imaging. Intratumor distributions were visualized by quantitative autoradiography of tumor tissue sections and compared to histology of the same or adjacent sections.Results:18F and223Ra accumulated in proportional amounts in whole Hu09-H3 tumors (r2= 0.82) and in microcalcified regions within these tumors (r2= 0.87). Intratumor distributions of18F and223Ra were spatially congruent in these microcalcified regions.Conclusions:18F-NaF and223RaCl2uptake are strongly correlated in heterogeneously distributed microcalcified regions of Hu09-H3 xenograft tumors, and thus, tumor accumulation of18F is predictive of223Ra accumulation. Hu09-H3 xenograft tumors appear to possess certain histopathological features found in patients with metastatic bone disease and may be useful in clarifying the relationship between administered223Ra dose and therapeutic effect.
