Differential engagement of cognitive and affective neural systems in pediatric bipolar disorder and attention deficit hyperactivity disorder.
Differential engagement of cognitive and affective neural systems in pediatric bipolar disorder and attention deficit hyperactivity disorder.
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DOI：
10.1017/s1355617709991019
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发表时间：
2010-01
影响因子：
2.6
通讯作者：
Pavuluri, Mani N.
中科院分区：
文献类型：
--
作者：
Passarotti, Alessandra M.;Sweeney, John A.;Pavuluri, Mani N.
关键词：
本研究探讨了儿童双相情感障碍（PBD）和注意缺陷多动障碍（ADHD）情绪加工认知控制的神经基础。17名未用药的PBD患者，15名未用药的ADHD患者和14名健康对照（HC）（平均年龄= 13.78 ± 2.47）进行了情绪效价Stroop任务，要求他们将情绪效价单词的颜色与两个相邻圆圈的颜色进行匹配。两个患者组的反应明显慢于HC，但在准确性方面没有组间差异。对大脑激活进行的体素方差分析显示，组与词价之间存在显著的相互作用[F（2，41）= 4.44; p = .02]。消极和积极的词也有类似的组间差异。对于消极与中性词，两个患者组表现出更大的激活背外侧前额叶皮层（DLPFC）和顶叶皮层相对于HC。PBD组在腹外侧前额叶皮层（VLPFC）和前扣带皮层（ACC）的激活程度高于HC组。ADHD组表现出减少VLPFC激活相对于HC和PBD组。在情绪处理的认知控制过程中，PBD患者比HC更大程度地使用VLPFC。ADHD患者显示相对于HC和PBD患者VLPFC参与减少。
This fMRI study investigates the neural bases of cognitive control of emotion processing in pediatric bipolar disorder (PBD) and attention deficit hyperactivity disorder (ADHD). Seventeen un-medicated PBD patients, 15 un-medicated ADHD patients, and 14 healthy controls (HC) (mean age = 13.78 ± 2.47) performed an emotional valence Stroop Task, requiring them to match the color of an emotionally valenced word to the color of either of two adjacent circles. Both patient groups responded significantly slower than HC, but there were no group differences in accuracy. A voxel-wise analysis of variance on brain activation revealed a significant interaction of group by word valence [F (2,41) = 4.44; p = .02]. Similar group differences were found for negative and positive words. For negative versus neutral words, both patient groups exhibited greater activation in dorsolateral prefrontal cortex (DLPFC) and parietal cortex relative to HC. The PBD group exhibited greater activation in ventrolateral prefrontal cortex (VLPFC) and anterior cingulate cortex (ACC) relative to HC. The ADHD group exhibited decreased VLPFC activation relative to HC and the PBD group. During cognitive control of emotion processing, PBD patients deployed the VLPFC to a greater extent than HC. The ADHD patients showed decreased VLPFC engagement relative to both HC and PBD patients.