Gender Affects Survival for Medulloblastoma Only in Older Children and Adults: A Study From the Surveillance Epidemiology and End Results Registry
Gender Affects Survival for Medulloblastoma Only in Older Children and Adults: A Study From the Surveillance Epidemiology and End Results Registry
复制标题
DOI：
10.1002/pbc.21832
复制
发表时间：
2009-01-01
影响因子：
3.2
通讯作者：
Fisher, Paul G.
中科院分区：
文献类型：
--
作者：
Curran, Emily K.;Sainani, Kristin L.;Fisher, Paul G.
男性髓母细胞瘤（MB）的发病率高于女性，但性别对生存率的影响尚不清楚。研究产生了相互矛盾的结果，可能是由于样本量小或研究人员如何定义MB的差异。我们的目标是使用大量数据集和严格的MB定义标准来确定性别对MB生存的影响。Procedure.从1973年到2002年，使用监测流行病学和最终结果（SEER-9）登记处确定了1,226名受试者（763名男性和463名女性）的样本。严格定义MB以排除非小脑胚胎性肿瘤（原始神经外胚层肿瘤）。因为已知< 3岁的儿童具有较差的存活率，所以患者按诊断时年龄< 3岁（95名男性，82名女性）和> 3岁（668名男性，381名女性）分层。结果总体而言，男性和女性之间的生存率无显著差异（对数秩P=0.22）。然而，在> 3年的受试者中，女性的生存率显著高于男性（对数秩P=0.02）。在< 3岁的儿童中，女性生存率较低的趋势不显著（中位生存期：男性27个月，女性13个月;对数秩P=0.24）。年龄组和性别之间的相互作用具有统计学意义（P=0.03）。结论MB女性仅在> 3年的受试者中具有生存优势。在小于3耳的儿童中，女性甚至可能有更差的结果。性别对MB生存率和发病率的影响需要进行额外的生物学研究，并且在患有NO. Pediatr Blood Cancer的非常年幼的儿童中可能不同2009;52：60-64。(c)2008 Wiley-Liss，Inc.
Background Males have a higher incidence of medulloblastoma (MB) than females, but the effect of gender on survival is unclear. Studies have yielded conflicting results, possibly due to small sample sizes or differences in how, researchers defined MB. We aimed to determine the effect of gender on survival in MB using a large data set and strict criteria for defining MB. Procedure. A sample of 1,226 subjects (763 males and 463 females) was identified from 1973 to 2002, using the Surveillance Epidemiology and End Results (SEER-9) registry. MB was strictly defined to exclude non-cerebellar embryonal tumors (primitive neuro-ectodermal tumors). Because children < 3 years of age are known to have worse Survival, patients were stratified by age < 3 years at diagnosis (95 males, 82 females) and > 3 years (668 males, 381 females). Results. Overall, there was no significant difference in survival between males females (log rank P=0.22). However, among Subjects > 3 years, females had significantly greater survival than males (log rank P=0.02). In children < 3 years, there was a non-significant trend toward poorer survival in females (median survival: males 27 months, females 13 months; log rank P=0.24). This interaction between age group and gender was statistically significant (P=0.03). Conclusion. Females with MB have a survival advantage only in subjects > 3 years. In children < 3 ears, females may even have poorer outcome. The effect of gender on survival and incidence in MB warrants additional biologic investigation, and may differ in very young children with NO. Pediatr Blood Cancer 2009;52:60-64. (c) 2008 Wiley-Liss, Inc.