F-actin cytoskeletal organization in intervertebral disc health and disease
F-actin cytoskeletal organization in intervertebral disc health and disease
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DOI：
10.1042/bst0350683
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发表时间：
2007-08-01
影响因子：
3.9
通讯作者：
Blain, E. J.
中科院分区：
文献类型：
--
作者：
Li, S.;Duance, V. C.;Blain, E. J.
细胞骨架，在大多数细胞类型中，包括这里描述的椎间盘，包括微丝、微管和中间丝，在许多基本细胞事件中起重要作用，包括细胞分裂、运动、蛋白质运输和分泌。细胞骨架对通讯也至关重要；例如，f -肌动蛋白（丝状肌动蛋白）细胞骨架网络结构的改变会影响细胞与细胞外基质之间的通信，潜在地损害组织的平衡。尽管迄今为止的研究有限，但本文旨在回顾当前关于椎间盘细胞中f -肌动蛋白细胞骨架元件组织的知识，f -肌动蛋白与病理的差异及其对机械转导的影响。
The cytoskeleton, which in most cell types, including the intervertebral disc described here, comprises microfilaments, microtubules and intermediate filaments, plays important functions in many fundamental cellular events, including cell division, motility, protein trafficking and secretion. The cytoskeleton is also critical for communication; for example, alterations to the architecture of the F-actin (filamentous actin) cytoskeletal networks can affect communication between the cells and the extracellular matrix, potentially compromising tissue homoeostasis. Although there are limited studies to date, this paper aims to review current knowledge on F-actin cytoskeletal element organization in intervertebral disc cells, how F-actin differs with pathology and its implications for mechanotransduction.