CXC chemokine ligand 12 (CXCL12) and its receptor CXCR4
CXC chemokine ligand 12 (CXCL12) and its receptor CXCR4
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DOI：
10.1007/s00109-014-1123-8
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发表时间：
2014-05-01
影响因子：
4.7
通讯作者：
Nagasawa, Takashi
中科院分区：
文献类型：
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作者：
Nagasawa, Takashi
趋化因子最初因其能够决定白细胞的迁移和活化而被认识。然而，CXC趋化因子配体12（CXCL12，也称为基质细胞衍生因子 - 1）及其受体CXCR4是首个被证明对发育过程至关重要的趋化因子和受体，这些发育过程包括造血干细胞（HSCs）的归巢和维持、免疫细胞的产生、原始生殖细胞（PGCs）的归巢、心脏发生、某些器官中动脉血管分支以及特定类型神经元的适当组装。这篇综述聚焦于哺乳动物中CXCL12 - CXCR4信号传导的病理生理相关性。
Chemokines were recognized originally for their ability to dictate the migration and activation of leukocytes. However, CXC chemokine ligand 12 (CXCL12, also known as stromal cell-derived factor-1) and its receptor CXCR4 are the first chemokine and receptor that have been shown to be critical for developmental processes, including homing and maintenance of hematopoietic stem cells (HSCs), production of immune cells, homing of primordial germ cells (PGCs), cardiogenesis, arterial vessel branching in some organs, and appropriate assemblies of particular types of neurons. This review focuses on the pathophysiological relevance of CXCL12-CXCR4 signaling in mammals.